| LU Wen-bin,YU Jing-ping,NI Xin-chu,WANG Jian,JIN Jian-hua,DENG Ling-hui,DENG Jian-zhong,SUN Zhi-qiang,SUN Su-ping.Relation between tumor pathologic response to concurrent chemo-radiotherapy and changes of serum VEGF level and its influence on the efficacy and prognosis in patients with esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2013,33(3):299-302 |
| Relation between tumor pathologic response to concurrent chemo-radiotherapy and changes of serum VEGF level and its influence on the efficacy and prognosis in patients with esophageal carcinoma |
| Received:January 15, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.020 |
| KeyWords:Esophageal carcinoma Pathology response Vascular endothelial growth factor Chemo-radiosensitivity Efficacy Prognosis |
| FundProject:江苏省卫生厅指导性科研项目(Z201220);常州市卫生局重大项目(ZD201105);常州市科技支撑社会发展项目(CE20125021) |
| Author Name | Affiliation | E-mail | | LU Wen-bin | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | YU Jing-ping | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | NI Xin-chu | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | WANG Jian | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | JIN Jian-hua | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | DENG Ling-hui | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | DENG Jian-zhong | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | SUN Zhi-qiang | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | SUN Su-ping | Department of Radiotherapy, the Changzhou Second People’s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | ssp56@126.com |
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| Abstract:: |
| Objective To observe the relation between pathologic tumor response to concurrent chemo-radiotherapy and the serum VEGF level, and to explore its corresponding influence on the efficacy and prognosis in patients with esophageal carcinoma.Methods Totally 46 cases of patients with esophageal cancer who received concurrent chemo-radiotherapy were enrolled. The gastroscopy and pathologic examination were conducted before and 4 weeks afterwards. Meanwhile, the serum VEGF level and X-ray barium of esophageal image were measured before, 4 weeks later and after the radiotherapy. The relation between the tumor pathologic response and the changes of the serum VEGF level and its influence on the efficacy and prognosis were analyzed. Results There were 18 cases (85.7%), 7 cases (53.8%) and 6 cases (50.0%) whose serum VEGF level dropped in the severe, moderate and mild group, respectively, and significant differences among these groups(χ2=6.072, P<0.05). There were 19 cases (90.5%), 5 cases (38.5%) and 4 cases (33.3%) whose response measured as effective in the severe, moderate and mild group, respectively, and significant differences among these groups(χ2=14.289,P<0.05)). The 2-year survival rates of the severe, there was no statistically difference between the severe and mild group on OS. There were 22 cases (71.0%), 6 cases(40.0%) and 4 cases (33.3%) whose response measured as effective in the serum VEGF level drop and increase group, respectively, and significant differences between these groups(χ2=14.289,P<0.05)).Conclusions The tumor pathologic response during chemo-radiotherapy and the changes of the serum VEGF lever may predict the curative effect of chemo-radiotherapy in the patients with esophageal cancer. To monitor the tumor pathologic response and the changes of the serum VEGF levels may be valuable for individualized treatment for esophageal cancer patients. |
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