| ZHANG Tian,YUAN Hui-min,MAO Kai,REN Ye,REN Ji-chen,LIU De-zhi,WANG Bin,WANG Zong-ye.Change of serum tumor markers and short-term efficacy after radiotherapy in advanced non-small cell lung cancer patients[J].Chinese Journal of Radiological Medicine and Protection,2013,33(3):290-293 |
| Change of serum tumor markers and short-term efficacy after radiotherapy in advanced non-small cell lung cancer patients |
| Received:January 30, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.018 |
| KeyWords:Tumor marker CEA CA125 CYFAR21-1 SCC Radiotherapy Non-small cell lung cancer |
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| Abstract:: |
| Objective To investigate the change of the serum levels of CEA, CYFAR21-1, SCC, CA125 in advanced non-small cell lung cancer patients before and after radiotherapy retrospectively and to explore the relationship between the change of serum tumor markers and the short-term efficacy of radiotherapy.Methods The serum levels of CEA, CYFAR21-1, SCC, CA125 in 205 cases with advanced non-small cell lung cancer were detected( by electro-chemiluminescence immunoassay method) before and after radiotherapy,and the short-term efficacy of radiotherapy was assessed (RECIST 1.1 edition) at the same time. The changes in tumor markers and the short-term efficacy were analyzed. Results Totally 113 patients achieved response of short-term efficacy after radiotherapy, and the effective rate of the short-term efficacy was 55.1%. Among these 113 patients, the serum levels of tumor markers decreased significantly after radiotherapy(t=3.224, 2.896, 3.137, 3.219, P<0.05). The serum levels of tumor markers in patients with stage Ⅲ and Ⅳ decreased after radiotherapy (t=2.484, 2.445, 2.148, 2.109, P<0.05;t=2.072, 2.857, 2.277, 2.436, P<0.05). Among 92 patients who did not achieve response of short-term efficacy, the serum level of tumor markers increased significantly after radiotherapy(t=2.224, 2.005, 2.261, 2.545, P<0.05).For the patient who achieved response of radiotherapy with tumor markers decreased,the short-term efficacy was significantly better than the group of which tumor maker increased (χ2=80.001, P<0.01). Conclusions The serum levels of CEA, CYFAR21-1, SCC, CA125 can be used for assessment of short-term efficacy after radiotherapy in advanced non-small cell lung cancer patients. |
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