| NI Xin-ye,QIAN Nong,LIN Tao,NIE Bin,SUN Zhi-qiang,SUN Su-ping.Radiosensitization effect of gold nanoparticles modified by sodium glycididazole on lung adenocarcinoma cell A549[J].Chinese Journal of Radiological Medicine and Protection,2013,33(3):265-268 |
| Radiosensitization effect of gold nanoparticles modified by sodium glycididazole on lung adenocarcinoma cell A549 |
| Received:August 09, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.012 |
| KeyWords:Sodium glycididazole Gold nanoparticles Radiosensitization Lung adenocarcinoma cell/A549 |
| FundProject: |
| Author Name | Affiliation | | NI Xin-ye | Department of Radiation Oncology, Second People ’s Hospital of Changzhou, Nanjing Medical University, Changzhou 213003, China | | QIAN Nong | Department of Radiation Oncology, Second People ’s Hospital of Changzhou, Nanjing Medical University, Changzhou 213003, China | | LIN Tao | Department of Radiation Oncology, Second People ’s Hospital of Changzhou, Nanjing Medical University, Changzhou 213003, China | | NIE Bin | Department of Radiation Oncology, Second People ’s Hospital of Changzhou, Nanjing Medical University, Changzhou 213003, China | | SUN Zhi-qiang | Department of Radiation Oncology, Second People ’s Hospital of Changzhou, Nanjing Medical University, Changzhou 213003, China | | SUN Su-ping | Department of Radiation Oncology, Second People ’s Hospital of Changzhou, Nanjing Medical University, Changzhou 213003, China |
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| Abstract:: |
| Objective To study the radiosensitization effect of gold nanoparticles modified by sodium glycididazole. Methods The sodium glycididazole was connected to gold nanoparticle, in dimension of about 18 nm, that had been modified with polyethylene glycol. The nanoparticle-swallowing efficiency of lung adenocarcinoma A549 cells was observed by a scanning electron microscope. Cells were divided into four groups: sodium glycididazole group, gold nanoparticles group, sodium glycididazole-gold nanoparticles group, and no drug control group. The radiosensitivity was detected by MTT and colony formation assays. Results Sodium glycididazole-gold nanoparticles could enter the cell cytoplasm and nucleus. The concentration of 0.003 mg/ml gold nanoparticles and sodium glycididazole-gold nanoparticles had no obvious cytotoxic effect. After irradiation of 2, 4, 6, 8 Gy, the cell survival of the sodium glycididazole-gold nanoparticle group was significantly lower than that of the other three groups (F=4.8, 14.5, 5.7, 7.6,P<0.05) and the D0 and Dq values of the sodium glycididazole-gold nanoparticle group were significantly lower than those of other three groups. Conclusion Sodium glycididazole-gold nanoparticles can enhance the radiosensitivity of lung adenocarcinoma cells. |
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