| DU Li,SUN Rong,MA Qiong,LI Zhi-hui,CAI Jin-ling,YANG Xiao-yun,MAN Qi-hang,CUI Yu-fang.Functional changes of HPA axis and Th1/Th2 imbalance in mice acutely exposed to 35 GHz millimeter-wave[J].Chinese Journal of Radiological Medicine and Protection,2013,33(3):252-255 |
| Functional changes of HPA axis and Th1/Th2 imbalance in mice acutely exposed to 35 GHz millimeter-wave |
| Received:September 27, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.009 |
| KeyWords:Millimeter-wave Stress Cytokine Hypothalamo-pituitary-adrenal axis |
| FundProject:毫米波国家重点实验室开放课题(K200909,K201225) |
| Author Name | Affiliation | E-mail | | DU Li | Institute of Radiation and Irradiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | SUN Rong | 南京东南大学毫米波国家重点实验室 | | | MA Qiong | Institute of Radiation and Irradiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | LI Zhi-hui | Institute of Radiation and Irradiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | CAI Jin-ling | Institute of Radiation and Irradiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | YANG Xiao-yun | Institute of Radiation and Irradiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | MAN Qi-hang | Institute of Radiation and Irradiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | CUI Yu-fang | Institute of Radiation and Irradiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | yufangc@vip.sina.com |
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| Abstract:: |
| Objective To investigate the expression pattern of cytokines and HPA axis hormones in acute stress reaction induced by 35 GHz millimeter-wave (MMW) radiation, and to explore the intrinsic association among the nerve-endocrine-immune system.Methods BALB/c mice were exposed to 35 GHz MMW with an average power density of 420 mW/cm2 for 60 s. The contents of IFN-γ and IL-4 in serum were measured and the expression level of hypothalamic corticotropin releasing hormone (CRH) and hippocampus glucocorticoid receptor (GR) in brain were analyzed at different time points after MMW exposure. Results The levels of IFN-γ and IL-4 and the cytokines of Th1 and Th2 increased to peak levels (t=-6.59,-2.28, P<0.05) at 3 d after exposure, and were still high up to 7 d after exposure. The ratio of Th1/Th2 (IFN-γ/IL-4) increased significantly at 1 d and 3 d post-exposure, which suggested that Th1/Th2 balance drifted to Th1 immune response. After acute MMW exposure, the level of hypothalamic CRH mRNA increased gradually and approached to a peak value at 7 d(t=-7.03, P<0.05). The expression level of hippocampal GR mRNA reached the peak at 3 d and then declined to control level. Meanwhile, the changes of hypothalamic CRH and hippocampal GR were consistent with the changes of their mRNA expressions. Conclusions Th1/Th2 balance in mice shifts toward Th1 after 35 GHz MMW acute exposure and the imbalance of Th1 shift can be improved obviously due to the feedback inhibition of IFN-γ and other cytokines by increased hypothalamic CRH and hippocampal GR induced by stress, which can alleviate the immune damage caused by excessive stress. |
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