| WAN Wei,DONG Fei,WANG Jing,et al.Clinical application of cytokines in acute iatrogenic radiation damage[J].Chinese Journal of Radiological Medicine and Protection,2013,33(3):228-231 |
| Clinical application of cytokines in acute iatrogenic radiation damage |
| Received:January 31, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.03.002 |
| KeyWords:Cytokine Hematopoietic growth factors Iatrogenic acute radiation disease |
| FundProject:卫生行业科研专项(201002009) |
| Author Name | Affiliation | E-mail | | WAN Wei | Department of Hematology, Peking University Third Hospital, Bejing 100191, China | | | DONG Fei | Department of Hematology, Peking University Third Hospital, Bejing 100191, China | | | WANG Jing | Department of Hematology, Peking University Third Hospital, Bejing 100191, China | | | FENG Kai-chao | 山西省肿瘤医院血液科 | | | SU Li-ping | 山西省肿瘤医院血液科 | | | SU Xu | 中国疾病预防控制中心辐射防护与核安全医学所 | | | KE Xiao-yan | Department of Hematology, Peking University Third Hospital, Bejing 100191, China | crystal_bmu@163.com |
|
| Hits: 4135 |
| Download times: 2527 |
| Abstract:: |
| Objective To explore the influence of hematopoietic growth factors on the TBI patients in the conditioning regimen for stem cell transplantation, and to evaluate the effect of cytokines on treatment of acute radiation disease. Methods The usage of hematopoietic growth factors, implantations and the side-effects of the patients and donors of TBI in the conditioning regimen for stem cell transplantation were retrospectively analysed from 1990 to 2012, and the effect and side-effects of cytokines on the hematopoietic function recovery and stem cell mobilization were observed. Results All patients recovered from their hematopoietic function except one died due to the side-effecs. The median time of white blood cell recover was 10 d in auto-SCT and 12 d in allo-SCT in the G-CSF group. The median day of platelet recovery was 11.67±1.53 in rhIL-11 arm and 13.70±6.27 in no rhIL-11 arm in the auto-SCT group. The incidence rates of dental ulcer and diarrhea in the TBI patients were 48% and 44%, respectively. The occurrence of side-effect was rare in the period of cytokines treatment, but was over 50% during stem cell mobilization. Conclusions Cytokines play very important roles in the hematopoietic function recovery and stem cell mobilization in the TBI patients. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
