| QI Huan-peng,LI Jian-bin,ZHANG Ying-jie,et al.Comparison of internal gross tumor volume for peripheral lung cancer based on four dimensional CT or three dimensional CT assisted with active breathing control[J].Chinese Journal of Radiological Medicine and Protection,2013,33(2):142-145 |
| Comparison of internal gross tumor volume for peripheral lung cancer based on four dimensional CT or three dimensional CT assisted with active breathing control |
| Received:June 26, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.02.008 |
| KeyWords:Peripheral lung cancer Active breathing control Three dimensional Four dimensional Internal gross tumor volume |
| FundProject:山东省自然科学基金(ZR2011HM004,ZR2009CL032);山东省科技发展计划项目(2012GSF11839) |
| Author Name | Affiliation | E-mail | | QI Huan-peng | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | | | LI Jian-bin | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | lijianbin@msn.com | | ZHANG Ying-jie | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | | | MA Zhi-fang | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | | | WANG Wei | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | | | LI Feng-xiang | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | | | WANG Su-zhen | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | | | LIANG Chao-qian | Department of Radiation Oncology, Shandong Cancer Hospital, Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, jinan 250117, China | |
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| Abstract:: |
| Objective To compare the differences of the position, volume and matching index(MI) between internal gross tumor volumes (IGTVs) determined by four methods based on four dimensional CT (4DCT) and three dimensional CT (3DCT) scans during free breathing and IGTV determined by one method based on 3DCT assisted with active breathing control. Methods Eighteen patients with peripheral lung cancer underwent 3DCT and 4DCT simulation scans during free breathing and then underwent 3DCT simulation scans in end inspiration hold (CTEIH) and end expiration hold (CTEEH). IGTVs were acquired using five methods: the gross tumor volme (GTV) contours from ten respiratory phases were combined into IGTV10; The GTV contours from 0% and 50% phases were combined into IGTV2; IGTVMIP was the GTV contour delineated from the maximum intensity projection (MIP); IGTV3D was acquired from the enlargement of 3DCT-based GTV by each spatial direction on the motion amplitude measured in 4DCT; IGTVABC was acquired by combining GTVs from CTEIH and CTEEH. Results In upper lobe group, there were significant differences in centroid position between IGTVABC and IGTV10 in lateral (LR), and IGTVMIP in anterio-posterior (AP) directions respectively (t=-2.377, -2.199, P＜0.05), and there were significant differences in centroid position between IGTVABC and IGTV2, IGTV3D in both LR and AP directions (t =-2.185 -2.767, P＜0.05). In lower lobe group, there were significant differences in centroid position between IGTVABC and IGTV10, IGTVMIP, IGTV3D in LR direction (t =3.950 4.543, P＜0.05).,Either in the upper lobe group or in the lower lobe group, IGTVABC was smaller than IGTV10 or IGTV3D significantly (Z =-3.180 -2.023, P＜0.05), and the MIs between IGTVABC and other IGTVs were larger in the upper lobe group thanin the lower lobe group significantly (Z=-2.419 -2.119, P＜0.05). Conclusions IGTVABC is not completely coincide with IGTVs acquired based on 4DCT or 3DCT during free breathing, and the spatial mismatch correlated with the tumor position, the spatial mismatch is more significant for middle-lower lobe tumor than upper lobe tumor. IGTVABC are larger than IGTV2 but smaller than other IGTVs acquired based on 4DCT and IGTV acquired based on 3DCT during free breathing. |
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