| ZHAO Fei,LI Yun,XUE Ying,GU Xi-hao,ZHANG Quan-shi,WEN Wan-xin.The quantitative study on high energy photon dose verification by PET imaging[J].Chinese Journal of Radiological Medicine and Protection,2013,33(1):85-89 |
| The quantitative study on high energy photon dose verification by PET imaging |
| Received:June 21, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.01.025 |
| KeyWords:High energy photon Positron emission tomography Dose verification Photon-nuclear reaction |
| FundProject:江苏高校优势学科建设工程资助项目(PAPD);江苏省环保科技项目(201020) |
| Author Name | Affiliation | E-mail | | ZHAO Fei | School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China | | | LI Yun | School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China | | | XUE Ying | School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China | | | GU Xi-hao | School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China | | | ZHANG Quan-shi | School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China | | | WEN Wan-xin | School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China | wxwen@suda.edu.cn |
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| Abstract:: |
| Objective To study positron yield quantitatively in different phantoms by means of PET imaging after high energy photon irradiation, and to investigate the feasibility of bio-dose verification by PET in high energy photon radiotherapy. Methods The phantoms (hydrogel, HDPE, inhomogeneous phantom) were scanned with PET 1 min later after exposure to 2, 4, 6, 8 Gy dose with/using 25 and 50 MV photon irradiation. The positron account rates were recorded every minute in PET scanning process and then fitted to get the half-lives of yielded nuclides. Positron distribution in each phantom was compared with dose distribution to investigate the relationship between positron activity and dose delivered. Results The half-lives of nuclides yielded in hydrogel and HDPE were supposed to be 2.23 and 19.47 min,respectively by fitting results, which had negligible difference with half-lives of 11C (20.2 min) and 15O (2.08 min). The positron amounts induced by 50 MV photon in hydrogel and HDPE were 3.88 and 3.86 times that of 25 MV photon, and increased in proportion to dose delivered. Except for build-up region and cavity, activity distributions in depth and off-axis were similar to dose distribution. Conclusions The amount and distribution of positron induced by high energy photon are related to dose delivered, and it is feasible to do dose verification with PET imaging in high energy photon radiotherapy. |
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