| GE Xiao-hui,GAO Xian-shu,LIN Qiang,et al.Relationship between 252Cf neutron ray intracavitary irradiation and esophageal carcinoma extensive infiltration on CT[J].Chinese Journal of Radiological Medicine and Protection,2013,33(1):46-49 |
| Relationship between 252Cf neutron ray intracavitary irradiation and esophageal carcinoma extensive infiltration on CT |
| Received:August 21, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.01.012 |
| KeyWords:Esophageal carcinoma/radiotherapy Intracavitary radiation/brachytherapy 252Cf CT extensive infiltration |
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| Abstract:: |
| Objective To explore the relationship between esophageal carcinoma extensive infiltration and lesion length and 252Cf intracavitary brachytherapy, and to evaluate its prognostic influence. Methods Thirty-two patients with esophageal carcinoma were treated by external beam and 252Cf intracavitary radiation. The patients were first treated with conventional fractionated radiation to a dose of 38 Gy over 4 weeks, with 5 daily fractions of 2 Gy per week, and then treated with external and intracavitary radiation concomitantly (4.0 Gy per fraction, once a week on every Saturday to 12 Gy in 3 fractions). The total dose of external irradiation was 50 Gy. Results The local control rate (LCR) at 1, 3 and 5 years was 93.75%, 76.70% and 65.75% in the patients with ≤5 cm lesion (NMT5 group), and 60.94%, 27.08% and 27.08% in the patients with >5 cm lesion (MT5 group), respectively (χ2=7.01,P<0.05). The 1-, 3-and 5-year survival rate (SR) was 93.75%, 56.25% and 43.75% in the NMT5 group, and 75.00%, 18.75%, 12.50% in the MT5 group, respectively (χ2=5.96,P<0.05). The LCR at 1, 3 and 5 years was 92.31%, 73.85% and 61.54% in the patients with ≤1.5 cm infiltration depth (NMT1.5 group), and 67.67%, 35.45% and 35.45% in the patients with >1.5 cm infiltration depth (MT1.5 group), respectively (χ2=3.87,P<0.05). The 1-, 3-and 5-year SR was 92.31%, 61.54% and 46.15% in the NMT1.5 group, and 73.68%, 21.05% and 15.79% in the MT1.5 group, respectively (χ2=6.24,P<0.05). LCR and SR in the patients with ≤5 cm lesion and ≤2 cm infiltration depth were significantly better than those with >5 cm lesion and >2 cm infiltration depth (χ2=10.09,7.97,P<0.05). Conclusions The patients with ≤5 cm lesion length or those with ≤1.5 cm infiltration depth, might become the most adaptable indication for 252Cf intracavitary radiation. In addition, those patients with ≤2 cm infiltration depth and ≤5 cm lesion length were also suitable for 252Cf intracavitary radiation. |
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