| CHEN Hai-xia,JIN Feng,WU Wei-li,GAN Jia-ying,LI Yuan-yuan.Analysis of treatment effect of chronomodulated chemotherapy plus concurrent intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma (NPC)[J].Chinese Journal of Radiological Medicine and Protection,2012,32(5):498-501 |
| Analysis of treatment effect of chronomodulated chemotherapy plus concurrent intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma (NPC) |
| Received:March 06, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.05.012 |
| KeyWords:Nasopharyngeal carcinoma Intensity-modulated radiotherapy Chronomodulated chemotherapy |
| FundProject:贵州省科技厅攻关项目(D2008-5) |
| Author Name | Affiliation | E-mail | | CHEN Hai-xia | Department of Head and Neck Oncology, Affiliated Hospital of Guiyang Medical College, Guizhou Tumor Hospital, Guiyang 550004, China | | | JIN Feng | Department of Head and Neck Oncology, Affiliated Hospital of Guiyang Medical College, Guizhou Tumor Hospital, Guiyang 550004, China | jinf8865@sina.com | | WU Wei-li | Department of Head and Neck Oncology, Affiliated Hospital of Guiyang Medical College, Guizhou Tumor Hospital, Guiyang 550004, China | | | GAN Jia-ying | Department of Head and Neck Oncology, Affiliated Hospital of Guiyang Medical College, Guizhou Tumor Hospital, Guiyang 550004, China | | | LI Yuan-yuan | Department of Head and Neck Oncology, Affiliated Hospital of Guiyang Medical College, Guizhou Tumor Hospital, Guiyang 550004, China | |
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| Abstract:: |
| Objective To evaluate the therapeutic effects, acute and late side-effects of cisplatin plus 5-fluorouracil (PF) schemed chronomodulated chemotherapy combined with concurrent intensity-modulated radiotherapy(IMRT) for nasopharyngeal carcinoma.Methods A total of 48 nasopharyngeal carcinoma patients treated with chronomodulated chemotherapy plus concurrent IMRT were retrospectively studied. The radiation doses prescribed to the gross target volume GTVnx of nasopharyngeal, to the positive neck lymphnodes GTVnd, to the clinical target volume CTV1, and to CTV2 were 73.92-77.88, 69.96, 60.06-66.00 and 50.96-56.00 Gy respectively. The Kaplan-Meier survival analysis was used to calculate the local-regional progression-free rate. The acute and late side-effects were graded according to RTOG radiation morbidity scoring criteria.Results The complete remission (CR) rate was 41.6% (20/48); the partial remission (PR) rate was 47.9% (23/48); the stable disease (SD) rate was 4.2% (2/48); and the local tumor control rate was 89.6%. Most of the patients had grade 1 to 2 acute side effects and grade 0 to 1 late side-effects. No grade 4 acute and late toxicity was observed. 1, 2, 4-year survival rates were 93.8%, 79.2% and 64.5%, respectively. The DVH analysis showed that IMRT improved the total dose and dose per-fraction to the target volume with considerable dose reduction of the normal structures at the same time. Conclusions PF chronomodulated chemotherapy plus concurrent intensity-modulated radiotherapy for NPC could improve therapeutic effects with satisfactory tolerance of the side effects. |
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