| WANG Yi,WANG Jun,CHENG Yun-jie,LIU Qing,ZHANG Ping,WU Feng-peng,WAN Xin,ZHANG Jun.Effect of TGF-β1 and IL-1β expression in serum on acute radiation-induced heart disease[J].Chinese Journal of Radiological Medicine and Protection,2012,32(5):488-491 |
| Effect of TGF-β1 and IL-1β expression in serum on acute radiation-induced heart disease |
| Received:February 16, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.05.009 |
| KeyWords:Three-dimensiond conformal radiotherapy Intensity modulated radiotherapy Radiation induced heart disease Transforming growth factor-β1 Human interleukin-1β |
| FundProject:河北省二〇〇九年医学科学研究重点课题(20090502) |
| Author Name | Affiliation | E-mail | | WANG Yi | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | WANG Jun | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | wangjun90@yahoo.com.cn | | CHENG Yun-jie | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | LIU Qing | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | ZHANG Ping | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | WU Feng-peng | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | WAN Xin | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | ZHANG Jun | Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective To evaluate the effect of TGF-β1 and IL-1β expression in serum on acute radiation-induced heart disease (RIHD) in patients with thoracic tumors.Methods Three-dimensional conformal radiotherapy (3D-CRT) or intensity modulated radiotherapy (IMRT) was delivered at 1.8-2.0Gy, 5 times per week to a total dose of 50-66Gy to 44 patients with lung cancer and 10 patients with esophagus cancer. The target and organs at risk dose distribution were analyzed by 3-dimensiond treatment planning system. The expressions of TGF-β1 and IL-1β in serum were detected by enzyme linked immunosorbent assay before and at the end of the irradiation. The cardiac injury was evaluated by detecting the cmyocardium creatase,cardiac troponin I (cTnI), electrocardiogram and cardiac function before and at the end of the irradiation within 90 d. The acute RIHD was evaluated by the Common Terminology Criteria V 3.0 (NCI-CTCAE 3.0). The expressions of TGF-β1 and IL-1β in the serum of RIHD patients with thoracic tumors were analyzed. Results The expression of TGF-β1 in serum was (888.4±41.1) μg/L before the irradiation and approached to (926.1±23.1) μg/L at the end of the radiotherapy.The expression level of TGF-β1 in the serum of acute RIDH group was (900.6±34.5) μg/L, higher than that of normal group [(865.7±47.0) μg/L, t=-2.646, P<0.05)]. The acute RIDH was correlated with the expression level of TGF-β1 before irradiation and the difference before and at the end of irradiation (r=0.378,0.311, P<0.05). The IL-1β expression had no significant difference before and after irradiation. The expression of TGF-β1 in serum before and at the end of irradiation had positive correlation with the expression of IL-1β at the end of the irradiation (r=0.416,0.389, P<0.05). Conclusions The expression of TGF-β1 in the serum of patients with thoracic tumor increases after irradiation and correlated with the acute RIHD, but the expression of IL-1β in serum has no relationship with RIHD. TGF-β1 could induce the expression of IL-1β at the end of the irradiation. |
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