| LIN Gen-lai,ZENG Zhao-chong,WU Zheng,et al.Effects of conventional fractionated three dimensional conformal radiotherapy on unresectable hepatocelluar carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2012,32(3):311-313 |
| Effects of conventional fractionated three dimensional conformal radiotherapy on unresectable hepatocelluar carcinoma |
| Received:August 01, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.03.023 |
| KeyWords:Hepatocellular carcinoma Three-dimensional conformal Radiotherapy |
| FundProject: |
| Author Name | Affiliation | | LIN Gen-lai | Zhongshan Hospital Cancer Center, Fudan University, Shanghai 200052, China | | ZENG Zhao-chong | Zhongshan Hospital Cancer Center, Fudan University, Shanghai 200052, China | | WU Zheng | Zhongshan Hospital Cancer Center, Fudan University, Shanghai 200052, China | | SUN Qiao | Zhongshan Hospital Cancer Center, Fudan University, Shanghai 200052, China | | ZHANG Xian | Zhongshan Hospital Cancer Center, Fudan University, Shanghai 200052, China | | CHEN Yi-xing | Zhongshan Hospital Cancer Center, Fudan University, Shanghai 200052, China |
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| Abstract:: |
| Objective To investigate the efficacy and toxicity of conventional fractionated three-dimensional conformal radiotherapy (3D-CRT) on unresectable hepatocelluar carcinoma(HCC).Methods Fifty two patients with unresectable HCC, all without extrahepatic metastases, were treated by 3D-CRT conducted 5 times a week with the total radiation dose of 36-66 Gy and a daily dose of 2 Gy. The curative effect was evaluated by CT scan to observe the maximum tumor size. Survival rates, survival time, and adverse responses were recorded.Results The total effective rate of the 52 patients was 69.2% with complete response (CR) in 2 patients and partial response (PR) in 34 patients. The incidence rate of radioactive hepatitis was 1.92%. The 1-, 2-, 3-, and 4-year survival rates were 57.7%, 34.6%, 23.1%, and 9.61% respectively, and the median survival time was 10.5 months. The 1-,2-,3-, and 4-year local control rates were 67%, 51.5%, 32.3%, and 2.24%, and the 1-, 2-, 3-, and 4-year distant metastasis rate were 17.2%, 23.5%, 36.7%, and 76.9% respectively. The intrahepatic metastases rate was 62.5% and 37.5% of the patients suffered from extrahepatic metastasis, including metastases of lung, bone, and retroperitoneal lymph nodes. The remission rate of the≥50 Gy group was 76.9%, significantly higher than that of the ≤50 Gy group (46.2%, χ2=10.72,P<0.05).There was no grade 3 or 4 acute toxicity, and two patients(3.84%) developed gastric or duodenal ulcer.Conclusions Conventional fractionated 3D-CRT evokes a rather effective response for unresectable HCC with acceptable toxicity. Radiation dose seems to be a significant prognostic factor in RT response for HCC. |
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