| WU Chen-bin,WU Jun-xin,XU Lu-ying,et al.Dosimetric study of influence of intensity modulated radiotherapy for nasopharyngeal carcinoma on hippocampal formation[J].Chinese Journal of Radiological Medicine and Protection,2012,32(3):297-300 |
| Dosimetric study of influence of intensity modulated radiotherapy for nasopharyngeal carcinoma on hippocampal formation |
| Received:August 04, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.03.019 |
| KeyWords:Hippocampal formation Nasopharyngeal carcinoma Intensity modulated radiotherapy |
| FundProject:福建省医学创新课题(2011-cx-15) |
| Author Name | Affiliation | E-mail | | WU Chen-bin | Department of Radiation Oncology, Provincial Clincal College of Fujian Medical University, Fuzhou 350014, China | | | WU Jun-xin | Department of Radiation Oncology, Provincial Clincal College of Fujian Medical University, Fuzhou 350014, China | Jun-xinWU@126.com | | XU Lu-ying | Department of Radiation Oncology, Provincial Clincal College of Fujian Medical University, Fuzhou 350014, China | | | LIN Shao-jun | Department of Radiation Oncology, Provincial Clincal College of Fujian Medical University, Fuzhou 350014, China | | | BAI Peng-gang | Department of Radiation Oncology, Provincial Clincal College of Fujian Medical University, Fuzhou 350014, China | | | ZHANG Xiu-chun | Department of Radiation Oncology, Provincial Clincal College of Fujian Medical University, Fuzhou 350014, China | | | PAN Jian-ji | Department of Radiation Oncology, Provincial Clincal College of Fujian Medical University, Fuzhou 350014, China | |
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| Abstract:: |
| Objective To evaluate the dosimetric characteristics of hippocampal formation (HF) in the intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC).Methods Fifty-nine NPC patients underwent IMRT.Simultaneous integrated boost technology was used to determine the doses for the target areas. The dose ranges of the HF were collected by dose-volume histogram. The influence of T stage on the exposure doses (Dmax,Dmean,D20,V10,V20,V30,and V40) were compared.Results The maximum dose for the HF (Dmax) ranged from 11.1 to 78.2 Gy(F=24.2,P<0.05) and the Dmean ranged from 3.2 to 44.6 Gy(F=16.3,P<0.05). The Dmax and Dmean of the T1-2 stage patients were (40.8±9.4) Gy and (12.5±5.1) Gy, respectively, both significantly lower than those of the T3-4 stage patients [(58.6±14.8) Gy, (20.9±9.3) Gy]. The mean exposed volume of the T4 stage patients was significantly larger than that of the T1 and T2 stages patients.Conclusions In the IMRT of NPC, the HF receives rather high irradiation dose. T stage is the main factor influencing the dose, especially T3 and T4 stages deserve serious attention. |
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