| WANG Hui,WANG Xin,PANG De-quan,FAN Yu-min,HU Lei,CHEN Jie,SU Hua-kun,YAO Lin.Experimental study of preventive effect of Anduolin (ADL) on radiation-induced lung injury in mice[J].Chinese Journal of Radiological Medicine and Protection,2012,32(3):278-281 |
| Experimental study of preventive effect of Anduolin (ADL) on radiation-induced lung injury in mice |
| Received:August 22, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.03.014 |
| KeyWords:Radiation-induced lung injury Anduolin Hydroxproline Transforming growth factor-β1 |
| FundProject: |
| Author Name | Affiliation | E-mail | | WANG Hui | Department of Radiation Oncology, Affiliated Hospital of Hebei United University, Tangshan 063000, China | | | WANG Xin | 天津医科大学附属肿瘤医院放疗科天津市"肿瘤防治"重点实验室 | | | PANG De-quan | Department of Radiation Oncology, Affiliated Hospital of Hebei United University, Tangshan 063000, China | | | FAN Yu-min | Department of Radiation Oncology, Affiliated Hospital of Hebei United University, Tangshan 063000, China | | | HU Lei | Department of Radiation Oncology, Affiliated Hospital of Hebei United University, Tangshan 063000, China | | | CHEN Jie | 063000 唐山, 河北联合大学药学院 | | | SU Hua-kun | 063000 唐山, 河北联合大学药学院 | | | YAO Lin | 063000 唐山, 河北联合大学公共卫生学院 | yaolin766@sohu.com |
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| Abstract:: |
| Objective To observe the preventive effect of Anduolin(ADL) on radiation-induced lung injury in mice.Methods Totally 180 of Kunming mice were randomly classified into six groups: normal control group (N),irradiation control group (R), irradiation plus low dose ADL group (L), irradiation plus middle dose ADL group (M), irradiation plus high dose ADL group (H), and irradiation plus Dexamethasone group (D). The mice except group N were irradiated with 20 Gy of 6 MV X-rays on whole lung. The mice in group L, M and H were given with ADL 1 d before irradiation and continued for 6 weeks after irradiation.At 2, 4 and 6 weeks after irradiation, the general situation and the lung pathological changes of mice were observed. The lung wet weight, collagen contents of the whole lung tissue, hydroxproline concentration, and TGF-β1 expression in the lung were also detected.Results Compared to the group R, the mice breathing rate, hydroxproline concentration, and TGF-β1 expression in the group L were not significantly changed. While in the groups M, H and D, the breathing rate, the generation of hydroxproline and the expression of TGF-β1 were decreased significantly (F=2.668-161.646,P<0.05). In addition, ADL alleviated the pathological changes on radiation-induced lung injury in mice.Conclusions ADL might have the preventive effect on radiation-induced lung injury in mice. |
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