| SONG Na-ling,MENG Ai-min,WANG Yue-ying,et al.Inhibitory effect of 17aα-D-homo-ethynylestradiol-3-acetae combined with irradiation on melanoma B16 growth[J].Chinese Journal of Radiological Medicine and Protection,2012,32(3):233-235 |
| Inhibitory effect of 17aα-D-homo-ethynylestradiol-3-acetae combined with irradiation on melanoma B16 growth |
| Received:December 22, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.03.003 |
| KeyWords:17aα-D-homo-ethynylestradiol-3-acetae B16 melanoma Radiation therapy Tumor inhibition efficiency |
| FundProject:国家自然科学基金(81072237);天津市自然科学基金重点项目(11JCZDJC19100) |
| Author Name | Affiliation | E-mail | | SONG Na-ling | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | | | MENG Ai-min | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | | | WANG Yue-ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | Wyytj@yahoo.com.cn | | WU Hong-ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | | | HE Xin | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | | | LI De-guan | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | | | WANG Xiao-chun | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | | | ZHANG Heng | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | | | LU Lu | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China | |
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| Abstract:: |
| Objective To investigate the antitumor effect of 17aα-D-homo-ethynylestradiol-3-acetae on the mice transplanted with melanoma (B16) tumor cells, and to explore the possible synergistic effect with irradiation.Methods IRM-2 mice transplanted with B16 cells were randomly classified into control group, irradiation group, 17aα-D-homo-ethynylestradiol-3-acetae drug (high dose, medium dose, low dose) groups, and drug and irradiation combination group. Mice in drug group and the combination group were intraperitoneally injected with 5, 7.5, and 10 mg/kg drug for 7 days. Mice in the irradiation and combination group received 1 Gy total body irradiation at 4 d after drug injection and then once a day for 5 days. The tumor inhibition efficiency, the number of bone marrow cells, thymus indices, and spleen indices were evaluated.Results Tumor weights in each drug group were significantly lower than those of the control(t=4.58,9.07,6.67,P <0.05). Drug combinated with 137Csγ-rays enhanced the antitumor effect so that the tumor weights in the combination group were significantly decreased (t=8.06,10.35,6.71,P <0.05) in comparison with the control groups. Moreover, the numbers of marrow nucleated cells, thymus index and spleen index in the drug group were higher than those in the control group(t=2.64,3.80,2.84,P <0.05).Conclusions 17aα-D-homo-ethynylestradiol-3-acetae can inhibit cell growth of Bl6 melanoma in mice and may also have radioprotective effect on the hematopoietic system and immune system of mice. |
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