| HAN Fei,XIAO Wei-wei,WANG Han-yu,HUANG Ying,DENG Mei-ling,ZHAO Chong,LU Tai-xiang.Influence of intensity-modulated radiotherapy on tumor regression in nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2012,32(2):204-206 |
| Influence of intensity-modulated radiotherapy on tumor regression in nasopharyngeal carcinoma |
| Received:August 26, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.02.024 |
| KeyWords:Nasopharyngeal carcinoma|Intensity-modulated radiotherapy|Conventional radiotherapy|Tumor regression mode|Radiation biology |
| FundProject: |
| Author Name | Affiliation | E-mail | | HAN Fei | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China | | | XIAO Wei-wei | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China | | | WANG Han-yu | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China | | | HUANG Ying | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China | | | DENG Mei-ling | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China | | | ZHAO Chong | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China | | | LU Tai-xiang | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China | lutx@sysucc.org.cn |
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| Abstract:: |
| Objective To retrospectively analyze the influence of intensity-modulated radiotherapy (IMRT) on tumor regression in primary nasopharyngeal carcinoma (NPC). Methods 272 patients with NPC received radical radiotherapy alone, 196 by IMRT with a total treatment time of 6 weeks, and 76 by bilateral field conventional radiotherapy (CRT) with the total treatment time of 7 weeks. Results By the end of radiotherapy, the primary tumor and neck lymph node residual rates of the IMRT group were 36.7% and 44.2%, respectively, both significantly higher than those of the CRT group(21.1% and 26.6%, χ2=6.15, 3.99,P＜0.05). Three months after the radiotherapy, residual lesions were observed at the nasopharynx or neck lymph nodes in 12 of the IMRT group, with a residual rate of 6.1%, not significantly different from that of the CRT group (9.2%, 7/76). The 12 residual lesions of the IMRT group all vanished completely 4-9 months after the radiotherapy. Conclusions There is an obvious difference in regressive mode between IMRT and CRT technique in NPC treatment. At the end of IMRT, the tumor residual rate is slightly increased. However, the delivered dose of gross tumor volume (GTV) is sufficient, and the boost dose should not be delivered indiscreetly. |
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