| JIANG Xin,XIN Ying,LUO Jing-hua,CHANG Peng-yu,FENG Qi,QU Ya-qin.Therapeutic effects of gensenoside-Rg3 combined with radiotherapy on advanced non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2012,32(2):196-198 |
| Therapeutic effects of gensenoside-Rg3 combined with radiotherapy on advanced non-small cell lung cancer |
| Received:July 07, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.02.022 |
| KeyWords:Gensenoside-Rg3|Radiotherapy|Non-small cell lung cancer |
| FundProject:吉林省科技厅基金(200705221);吉林省发展与改革委员会基金(2010019-1) |
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| Abstract:: |
| Objective To study the efficacy and toxicity of gensenoside-Rg3 (Rg3) combined with radiotherapy on non-small cell lung cancer (NSCLC) at advanced stages (Ⅲ and Ⅳ). Methods Sixty-three patients with stage Ⅲ or ⅣNSCLC were divided randomly into two groups: treatment group (n=35) treated with Rg3 combined with radiotherapy and control group (n=28) treated with radiotherapy alone.The efficacy and side effects were compared after the treatment. Results The response rate (CR+PR) of the treatment group was 57.14%, significantly higher than that of the control group (32.14%, χ2=3.91, P<0.05). The median survival time of the treatment group was 14.2 months, significantly longer than that of the control group (11.2 months, χ2=2.07,P<0.05). The one-year survival rate of the treatment group was 62.86%, significantly higher than that of the control group (39.29%, χ2=4.40,P<0.05). The incidence rates of side effects of the treatment group were all lower than those of the control group, but there were not significant difference. Conclusions Gensenoside-Rg3 combined with radiotherapy is effective for advanced stage NSCLC, with attenuation and synergistic effects. |
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