| MA Chang-sheng,LU Jie,LIU Tong-hai,et al.Application of deformable registration and empirical calculation method to calculate the accumulated dose for normal tissues and organs at risks in lung cancer radiotherapy plans[J].Chinese Journal of Radiological Medicine and Protection,2012,32(1):70-73 |
| Application of deformable registration and empirical calculation method to calculate the accumulated dose for normal tissues and organs at risks in lung cancer radiotherapy plans |
| Received:March 08, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.01.017 |
| KeyWords:Deformable registration Accumulated dose Lung cancer |
| FundProject:山东省自然科学基金(ZR2010HM071) |
| Author Name | Affiliation | E-mail | | MA Chang-sheng | Shandong Provincial Key Laboratory of Radiooncology, Department of Radiation Oncology Physics of Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China | | | LU Jie | Shandong Provincial Key Laboratory of Radiooncology, Department of Radiation Oncology Physics of Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China | | | LIU Tong-hai | Shandong Provincial Key Laboratory of Radiooncology, Department of Radiation Oncology Physics of Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China | | | ZHANG Gui-fang | Shandong Provincial Key Laboratory of Radiooncology, Department of Radiation Oncology Physics of Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China | | | CHEN Jin-hu | Shandong Provincial Key Laboratory of Radiooncology, Department of Radiation Oncology Physics of Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China | | | YIN Yong | Shandong Provincial Key Laboratory of Radiooncology, Department of Radiation Oncology Physics of Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, China | yinyongsd@yahoo.com.cn |
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| Abstract:: |
| Objective To evaluate the accumulated doses to normal tissues and organs at risks (OARs) of patients with lung cancer in radiotherapy plans by using the deformable registration method,and make comparison with the empirical calculation method. Methods Ten patients with lung cancer were analyzed retrospectively. 3D-CRT or IMRT plans were designed before treatment. CT to simulator was rescanned and the same treatment plan was redesigned during radiotherapy. Based on the deformable registration method, the Mimvista software was used to calculate the accumulated doses to normal tissues and OARs in two CT images respectively. The empirical estimation algorithm was calculated by the linear relationship between the fractions and the total prescribed dose. Results The target coverage of patients had no significant difference in two plans. There were no significant differences in all the dose volume parameters for normal tissues and OARs, except the mean dose to right lung(t=2.98,P<0.05) when the the same plan was conducted in position-setting and reposition CT images. Conclusions The empirical estimation for the accumulated dose could be used to evaluate the dose and volume parameters for normal tissues and OARs in lung cancer by the same plan. |
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