| ZHANG Bing-hua,FEI Jin-xiu,GUO Yong-bo,et al.Effect of high power pulse microwave on morphological changes of pancreas and nitric oxide and endothelin in blood serum in rats[J].Chinese Journal of Radiological Medicine and Protection,2012,32(1):52-55 |
| Effect of high power pulse microwave on morphological changes of pancreas and nitric oxide and endothelin in blood serum in rats |
| Received:December 01, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2012.01.012 |
| KeyWords:High power pulse microwave Nitric oxide Endothelin Pancreas |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHANG Bing-hua | 323 Hospital of PLA, Xi'an 710054, China | zbhyy7610@sohu.com | | FEI Jin-xiu | 323 Hospital of PLA, Xi'an 710054, China | | | GUO Yong-bo | 323 Hospital of PLA, Xi'an 710054, China | | | WANG Hong-xia | 323 Hospital of PLA, Xi'an 710054, China | | | SONG Xiao-feng | 323 Hospital of PLA, Xi'an 710054, China | | | WEN Qin-sheng | 第四军医大学唐都医院消化科 | | | HUANG Yu-xin | 第四军医大学唐都医院消化科 | |
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| Abstract:: |
| Objective To observe the morphological changes of rats' pancreas and nitric oxide(NO) and endothelin(ET) in the blood serum in rats after exposure to different pulses of high power pulse microwave (HPPMW). Methods SD-rats were irradiated with 104, 105 and 4×105 pulses of HPPMW, respectively. After gloss observation, the histopathological changes of pancreas were observed through biological microscope and electroscope. The changes of amylase, nitric oxide and endothelin in blood serum were detected by biochemical and radio-immunological methods. Results Compared with the blank control, no apparent abnormality could be observed in the pancreas of all groups. The dilatation of capillary could be observed in each experimental group by microscope. The ultrastructure changes of pancreas were most serious in 4×105 pulse group, especially at 24 and 48 h after irradiation. Compared with the control group, the levels of serum amylase were decreased (F=12.58,11.73, P<0.05), while ET were increased (F=4.50, 4.49, P<0.05) at 24 and 48 h after irradiation. The levels of NO in serum were increased (F=17.51, 41.72, 19.98,32.64, P<0.05) at each time-point. The level of NO went up with the increase of pulses. Conclusions HPPMW has damage effects on the pancreas in rats. The pulses with the pancreas can lead to severity of the damage. The mechanism of HPPMW may be involved in the enhancement of ET and NO in serum. |
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