| ZHU Wei-guo,TAO Guang-zhou,LI Tao,et al.Effects of postoperative 3-dimensional conformal radiotherapy on lymph node positive patients after radical resection of esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2011,31(5):571-574 |
| Effects of postoperative 3-dimensional conformal radiotherapy on lymph node positive patients after radical resection of esophageal carcinoma |
| Received:March 04, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.05.017 |
| KeyWords:Esophageal neoplasms Radiotherapy Lymphatic node Metastasis |
| FundProject: |
| Author Name | Affiliation | | ZHU Wei-guo | Department of Radiation Oncology, First Peoples Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China | | TAO Guang-zhou | Department of Radiation Oncology, First Peoples Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China | | LI Tao | Department of Radiation Oncology, First Peoples Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China | | YU Chang-hua | Department of Radiation Oncology, First Peoples Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China | | PENG Jin | Department of Radiation Oncology, First Peoples Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China | | HAN Ji-hua | Department of Radiation Oncology, First Peoples Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China | | CHEN Xiao-fei | Department of Radiation Oncology, First Peoples Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China |
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| Abstract:: |
| Objective To analyze the significance of postoperative radiotherapy for lymph node positive patients after radical resection of esophageal carcinoma. Methods Two hundred and sixty patients with esophageal squamous cell cancer, aged ≤70, with the performance status score of 0-1, who had undergone radical resection were divided into 2 equal groups: surgery alone group (Group A) and surgery plus radiotherapy group (Group B).Group A was classified into 3 sub-groups:Group A1 ( n=42) without lymph node involvement, Group A2 (n=43) with 1 to 3 involved lymph nodes, and Group A3 (n=45) with ≥4 involved lymph nodes.Group B was classified into 3 sub-groups:Group B1 (n=43) without lymph node involvement, Group B2 (n=44) with 1 to 3 involved lymph nodes, and Group B3 (n=43) with ≥4 involved lymph nodes.The patients were followed up till death. Results The 1-,3-, and 5-year overall survival rates of Group A were 71.5％, 35.4％ and 20％, respectively, all significantly lower than those in Group B (76.2％,48.5％ and 36.2％, respectively, χ2=7.822,P<0.05). The 1-, 3-, and 5-year survival rates of Groups A1 were 83.3％, 52.3％, and 38.1％,respectively, all not significantly different from those of Group B1 (81.3％, 58.1％, and 46.5％,respectively, χ2=0.283,P>0.05). The 1-, 3-, and 5-year survival rates of Groups A2 were 69.8％,34.9％,and 18.6％,respectively, all significantly lower than those of Group B2 (77.3％,47.7％,and 40.9％,respectively, χ2=4.188,P<0.05). The 1-, 3-, and 5-year survival rates of Groups A3 were 62.2％,20％,and 4.4％,respectively, all significantly lower than those of Group B3 (69.8％,39.5％,and 20.9％,respectively, χ2=6.168,P<0.05). The 5-year metastatic lymph node rates of Groups A1 to A3 were 30.9％, 53.4％, and 66.7％,respectively, all significantly higher than those of Groups B1 to B3 (11.6％, 22.7％, and 30.2％,respectively, χ2=4.753,8.741, and 11.682,respectively, all P<0.05). The 5-year distant metastasis rates of Groups A1 to A3 were 11.9％, 20.9％, and 31.1％,respectively, all not significantly different from those of Groups B1 to B3(13.9％,20.4％,and 25.6％,respectively, χ2=0.079,0.003,and 0.203,respectively,all P>0.05). Conclusions Postoperative radiotherapy increases the survival rate of lymph node positive patients, but shows little efficacy on the lymph node negative patients. It reduces the occurrence of lymph node metastasis, even in the lymph node negative patients, and does not increase the morbidity of complications, especially that of anastomotic stenosis. The number of metastatic lymph node is one of the important factors affecting the survival of esophageal carcinoma. Distant metastasis increases along with the number of metastatic lymph nodes. |
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