| LIU Gui-mei,XIA Guang-rong,JIN Guo-hua,XU Yong-xiang,LI Xiao-bo,ZHANG Yun-quan,HE Wen.Therapeutic effect of three-dimensional conformal involved-field radiotherapy combined with chemotherapy on limited disease stage small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2011,31(5):567-570 |
| Therapeutic effect of three-dimensional conformal involved-field radiotherapy combined with chemotherapy on limited disease stage small cell lung cancer |
| Received:February 20, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.05.016 |
| KeyWords:Small cell lung cancer 3-dimensional conformal radiotherapy Chemotherapy Prognosis |
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| Abstract:: |
| Objective To analyze the therapeutic effect of three-dimensional conformal involved-field radiotherapy (3D-CRT)combined with chemotherapy on limited disease stage small cell lung cancer (LD-SCLC). Methods The clinical data of 85 patients of LD-SCLC treated with 3D-CRT at the dose of 2 Gy/fraction, 5 fractions per week for 5-7 weeks, with the median dose of 50 Gy (46-66 Gy), combined with 4-8 cycles chemotherapy, 64 males and 21 females, aged 29-76,were collected and analyzed. Results The complete remission rate, partial remission rate, stability rate, and total effective rate were 36.5% , 52.9% , 10.6% , and 89.4% , respectively. The median survival time was 18 months,with the 1-, 2-, and 3-year overall survival rates of 65.9%, 33.8%, and 15.9%, respectively. The local recurrence rate, distant metastasis rate, and local recurrence+distant metastasis rate were 15.2% (9/85), 49.2% (29/85), and 35.6% (21/85), respectively. Body weight, response to therapy,cycles for chemotherapy, and concurrent chemo-radiotherapy were all independent prognostic factors for LD-SCLC. Cox multivariable regression was used to analyze the prognostic factors. Conclusions Involved-field radiotherapy is effective for LD-SCLC. Distance metastasis is the main cause of treatment failure. |
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