| ZHANG Zi-cheng,HE Jin-guang,LI Bao-sheng,YIN Yong,LU Jie,WANG Zhong-tang,LI Hong-sheng,SUN Hong-fu,YI Yan,XU Jin.Clinical and dosimetric risk factors of acute radiation esophagitis in non-small cell lung cancer patients treated with three-dimensional conformal radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2011,31(5):559-563 |
| Clinical and dosimetric risk factors of acute radiation esophagitis in non-small cell lung cancer patients treated with three-dimensional conformal radiotherapy |
| Received:August 14, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.05.014 |
| KeyWords:Non-small cell lung cancer Three-dimensional conformal radiotherapy Acute radiation esophagitis |
| FundProject:国家自然科学基金(30670617) |
| Author Name | Affiliation | | ZHANG Zi-cheng | *Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | HE Jin-guang | 菏泽市立医院肿瘤科 | | LI Bao-sheng | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 | | YIN Yong | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 | | LU Jie | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 | | WANG Zhong-tang | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 | | LI Hong-sheng | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 | | SUN Hong-fu | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 | | YI Yan | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 | | XU Jin | 250117 济南,山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室 山东省医学科学院 |
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| Abstract:: |
| Objective To analyze the clinical and dosimetric risk factors for acute radiation esophagitis (ARE) in non-small cell lung cancer (NSCLC) patients treated with three-dimensional conformal radiotherapy (3D-CRT), and to find significant risk factors for clinical therapy. Methods A total of 102 NSCLC patients treated with 3D-CRT were retrospectively analyzed. ARE was scored according to the Radiation Therapy Oncology Group (RTOG) criteria with grade 2 or worse. Patients were divided into non-concurrent chemoradiotherapy group and concurrent chemoradiotherapy group. The clinical and dosimetric factors associated with grade 2 or worse ARE were analyzed using univariate logistic regression, multivariate logistic analysis and receiver operating characteristic (ROC) curve. Results There were no grade 4 or 5 ARE observed in the 102 patients. Nineteen developed grade 2, 15 developed grade 3.In non-concurrent chemoradiotherapy group, multivariate analysis showed that V55 was the only risk factor of grade 2/3 ARE. For ROC curve analysis, the cut-off point of V55 was 16.0 while the area under ROC curve was 0.870 (95%CI: 0.782-0.957,P<0.05). In concurrent chemoradiotherapy group, multivariate analysis showed that V35 and chemotherapy regimens during radiotherapy were risk factors of grade 2/3 ARE. The cut-off point of V35 was 23.75 while the area under ROC curve was 0.782 (95%CI: 0.636-0.927,P＜0.05). Vinorelbine and cisplatin regimen showed low incidence of ARE contrast with gemcitabine/docetaxel and cisplatin regimens (33.3% and 66.7%). Conclusions V55 is the only statistically significant risk factor associated with grade 2 or worse ARE for patients who don't accepted concurrent chemotherapy. V35 and chemotherapy regimens during radiotherapy are statistically significant risk factors associated with grade 2 or worse ARE for patients who accept concurrent chemotherapy. Vinorelbine and cisplatin regimen during radiotherapy shows low incidence of ARE. |
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