| FENG Xiao-qing,HU Zhi-yong,LIU Hua-qing,DING Xiao-fei,LI Bing-yan,ZHANG Zeng-li.Protective effects of parathyroid hormone on radiation-induced hematopoietic damage in mice[J].Chinese Journal of Radiological Medicine and Protection,2011,31(5):542-544 |
| Protective effects of parathyroid hormone on radiation-induced hematopoietic damage in mice |
| Received:October 12, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.05.008 |
| KeyWords:Parathyroid hormone Radiation damage Hematopoiesis |
| FundProject:江苏省自然科学基金(BK2009120) |
| Author Name | Affiliation | | FENG Xiao-qing | Department of Toxicology, School of Radiation Medicine and Public Health,Soochow University,Suzhou 215123,China | | HU Zhi-yong | Department of Toxicology, School of Radiation Medicine and Public Health,Soochow University,Suzhou 215123,China | | LIU Hua-qing | Department of Toxicology, School of Radiation Medicine and Public Health,Soochow University,Suzhou 215123,China | | DING Xiao-fei | Department of Toxicology, School of Radiation Medicine and Public Health,Soochow University,Suzhou 215123,China | | LI Bing-yan | Department of Toxicology, School of Radiation Medicine and Public Health,Soochow University,Suzhou 215123,China | | ZHANG Zeng-li | Department of Toxicology, School of Radiation Medicine and Public Health,Soochow University,Suzhou 215123,China |
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| Abstract:: |
| Objective To study the protective effects of parathyroid hormone (PTH) on radiation-induced hematopoietic damage in mice. Methods A total of sixty male C57 mice were irradiated by 60Co γ-rays to induce hematopoietic injuries, and then the mice were randomly divided into PTH and control group. The PTH-treated group was treated with PTH (80 μg ·kg-1 ·d-1) intraperitoneally everyday. The control group was given equivalent volume saline. Peripheral blood cell number, bone marrow mononuclear cell number, granulocyte-macrophage colony forming units(CFU-GM) and CD34 positive cells in bone marrow were detected. Results With the whole post-irradiation period, the WBC and bone marrow mononuclear cell numbers in PTH-treated mice were significantly higher than those in saline-treated mice(t=6.32, 9.19, 11.18, 7.44 and 4.42,P<0.05). The RBC numbers in PTH-treated mice were significantly higher than those in control mice at 10 d, 15 d and 20 d post-irradiation (t=6.48, 3.66 and 4.98, P<0.05). The PLT numbers in PTH-treated mice were significantly higher than those in control group at 5 and 30 d post-irradiation (t=2.57 and 3.10, P<0.05). PTH increased CD34 positive cell and CFU-GM numbers in bone marrow after irradiation(t=16.12, 7.82 and 20.00, P<0.05). Conclusions PTH could improve the hematopoietic recovery after irradiation. |
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