| ZENG Fa-gui,WANG Chuan-gao,DU Jie,et al.Dose-effect relationship of chromosome aberrations induced by different LET rays atlow doses[J].Chinese Journal of Radiological Medicine and Protection,2011,31(5):531-535 |
| Dose-effect relationship of chromosome aberrations induced by different LET rays atlow doses |
| Received:January 19, 2011 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.05.006 |
| KeyWords:Ionizing radiation Linear energy transfer Low doses Chromosome aberrations Dose-effect curve |
| FundProject:军队"十一五"科技攻关项目(08G143) |
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| Abstract:: |
| Objective To establish the dose-effect curves of chromosome aberrations in human peripheral blood lymphocytes induced by different LET rays, including 60Co γ-rays, 252Cf neutrons, 14 MeV neutrons and 12C heavy ions at low doses, respectively, in order to assess radiation-induced damages after occupational and accidental exposure. Methods Heparinized whole blood samples were irradiated with the various radiation devices and doses ranged from 0 to 1 Gy with the interval of 0.25Gy. Conventional chromosome culture method was applied with adding colchicines at the beginning and chromosome specimens were prepared after 48 h incubation. The Metafer scanning system was used for automatical finder of chromosome metaphases. The mathematic models were fitted according to aberration data obtained. Results At the dose range of 0-1 Gy, the math models of dic+r were linear for 60Co γ-rays and linear-quadratics for 252Cf neutrons, 14 MeV neutrons and 12C heavy ions. The models of ace were linear-quadratic for 60Co γ-rays and 12C heavy ion beams, and linear for 252Cf and 14 MeV neutrons. The models of total aberrations were linear-quadratic for all types of radiation. Conclusions High LET rays have higher biological effects in inducing chromosome aberrations yields compared with low LET rays. Moreover, the severity of damage is 252Cf > 14 MeV neutrons > 12C heavy ions > 60Co γ-rays in turn. Therefore, in the range of low doses, the dic+r may be a better target of radiation damage for high LET radiation. |
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