| MA Rui,YUAN Shu-yu,KONG Ling-hai,ZHANG Liang-an.Dose distribution of 125I seed sources in brachytherapy prostate cancer model[J].Chinese Journal of Radiological Medicine and Protection,2011,31(4):485-488 |
| Dose distribution of 125I seed sources in brachytherapy prostate cancer model |
| Received:April 12, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.04.030 |
| KeyWords:Brachytherapy TLDs Prostate cancer Iodine-125 seed source |
| FundProject: |
| Author Name | Affiliation | E-mail | | MA Rui | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192,China | | | YUAN Shu-yu | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192,China | | | KONG Ling-hai | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192,China | | | ZHANG Liang-an | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192,China | zhangla43@yahoo.com.cn |
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| Abstract:: |
| Objective To study the dose distribution of the radioactive 125I seeds sources in the treatment of prostate cancer and also to explore the more effective method for improving treatment planning system (TPS). Methods Choose the designated TPS and use TLDs dosimeter based on a prostate cancer model. Finally stimulated measurement was focused on dose distribution in prostate cancer. The number of 125I seed sources implanted was 89, each with 1.37×107 (±5%) Bq. Results Maximum dose of every layer ranged from 151 to 241 Gy, by 4.1% to 66.0% higher than the prescribed dose (145 Gy). The Minimum dose of every layer ranged from 101 to 128 Gy, by 12% to 30% higher than the prescribed dose. The maximum dose of normal tissue at 10 mm from the edge of model ranged from 46 to 91 Gy. The deviation was 44%-63% compared with the prescribed dose. Conclusions The designated TPS shows that it could be used as a practical guide for treatment of prostate cancer with the radioactive 125I seed sources. The research methods offered by the study can provide evaluation of the TPS. |
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