| FU Zhi-chao,CHENG Hui-hua,LI Dong-shi,et al.Genetic polymorphism of HIF-1α G1790A associated with radiosensitivity of nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2011,31(4):430-432 |
| Genetic polymorphism of HIF-1α G1790A associated with radiosensitivity of nasopharyngeal carcinoma |
| Received:June 08, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.04.013 |
| KeyWords:Hypoxia inducible factor 1α Single nucleotidepolymorphism Nasopharyngeal carcinoma Radiosensitivity |
| FundProject:福建省自然科学基金(2007J0284) |
| Author Name | Affiliation | | FU Zhi-chao | Department of Radiation Oncology, Fuzhou General Hospital, Clinical Medical College of Fujian Medical University,Fuzhou 350025,China
| | CHENG Hui-hua | Department of Radiation Oncology, Fuzhou General Hospital, Clinical Medical College of Fujian Medical University,Fuzhou 350025,China
| | LI Dong-shi | Department of Radiation Oncology, Fuzhou General Hospital, Clinical Medical College of Fujian Medical University,Fuzhou 350025,China
| | WANG Feng-mei | 350025 福建医科大学福州总医院临床医学院 南京军区福州总医院妇产科 | | LIN Gui-shan | Department of Radiation Oncology, Fuzhou General Hospital, Clinical Medical College of Fujian Medical University,Fuzhou 350025,China
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| Abstract:: |
| Objective To explore the association between the genetic polymorphism of hypoxia inducible factor 1α (HIF-1α) G1790A and the radiosensitivity of nasopharyngeal carcinoma. Methods A total of 189 patients with nasopharyngeal carcinoma treated with radical radiotherapy were followed-up for 3 years. The patients were divided into cured group with 135 cases and recurrence group with 54 cases by clinical follow-up results. PCR-RFLP was used to determine the mononucleotide genotypes of HIF-1α G1790A. Results The observed genotype frequencies of HIF-1α gene 1790 (G→A) for GG, GA and AA were 70.04%, 20.74%, 2.22% in cured group and 59.26%, 38.89%, 1.85% in recurrence group, respectively. The allele frequencies for G and A were 87.4%, 13.9% in cured groups and 78.7%, 21.3% in recurrence group, respectively, without significant difference in distribution of allele frequencies between the two groups(χ2=6.919,P=0.077). Conclusions The genetic polymorphisms of HIF-1α G1790A might be related with the radiosensitivity of nasopharyngeal carcinoma. |
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