| XU Long,PAN Xiu-jie,YANG Zhi-hua,CAO Zhen-shan,ZHU Mao-xiang.Effect of S-band microwave long-term intermittent irradiation on endocrine fuction in rats[J].Chinese Journal of Radiological Medicine and Protection,2011,31(3):294-298 |
| Effect of S-band microwave long-term intermittent irradiation on endocrine fuction in rats |
| Received:March 31, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.03.012 |
| KeyWords:Microwave Serum Endocrine |
| FundProject: |
| Author Name | Affiliation | | XU Long | Institute of Radiation Medicine, AMMS, Beijing 100850, China | | PAN Xiu-jie | Institute of Radiation Medicine, AMMS, Beijing 100850, China | | YANG Zhi-hua | Institute of Radiation Medicine, AMMS, Beijing 100850, China | | CAO Zhen-shan | Institute of Radiation Medicine, AMMS, Beijing 100850, China | | ZHU Mao-xiang | Institute of Radiation Medicine, AMMS, Beijing 100850, China |
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| Abstract:: |
| Objective To observe the effect of S-band micro-wave long-term intermittent irradiation on endocrine function in rats. Methods A total of 192 rats (male and female) were randomly divided into the sham-irradiation (normal control) groups and the irradiation groups. The irradiation groups were exposed with micro-wave at 3 dosages of 4, 10 and 20 mW/cm2 for 6 min twice a week for 12 weeks, while no administration was given to control group.The endocrine parameters in blood serum were examined by radioimmunoassay at 4,8,12 week during irradiation and 4 week post-irradiation. Results After the irradiation of S-band microwave, parts of the endocrine parameters changed. T3 in famale rats decreased at first and then increased, especially in 10 mW/cm2 group at 8 and 12 week, 20 mW/cm2 group at 4 and 12 week(t=-2.586, -2.642,-5.075,-4.365, P <0.05). FT3 in famale rats had the similar trend as T3, significantly lower in 4 and 10 mW/cm2 groups than that in the control group at 4 week (t=2.275, 2.510, P <0.05), then increased, especially in three irradiation groups at 12 week (t=-2.636, -2.851,-5.240, P <0.05). TSH decreased at 4 week, especially in 10 mW/cm2 group (t=2.300, P <0.05); and then increased in the irradiation groups at 20 mW/cm2 at 8 and 12 week (t=-2.838,-3.651, P <0.05). COR and ACTH in male rats showed changes in volatility, in which the 4,10 and 20 mW/cm2 groups at 8 week increased significantly (t=-2.772, -2.234, -2.505, P <0.05), while 20 mW/cm2 group at 12 week decreased significantly (t=3.067, P <0.05). E2 in female rats was slightly lower in irradiation groups at 4 week than the control group, then increased, especially in 10 mW/cm2 group at 8 week, three irradiation groups at 12 week (t=-2.322,-3.179, -2.655,-4.716, P <0.05),and returned to the normal at 4 week post-irradiation, significantly lower in 4 mW/cm2 group than that in the control group (t=2.250, P <0.05). T in male rats increased first and then decreased, especially in 10 mW/cm2 group at 8 week(t=-2.435, P <0.05). After exposure the above indexes restored to some extent. Conclusions The long-term intermittent irradiation of S-band microwave can cause adverse effects on the endocrine function of rats. |
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