| QIU Guo-qin,ZHU Cheng-long,DU Xiang-hui,et al.A dosimetric comparison of three plans in simultaneous integrated boost intensity-modulated radiotherapy in cervical esophageal carcinoma undergoing prophylactic lymphatic irradiation[J].Chinese Journal of Radiological Medicine and Protection,2011,31(1):46-49 |
| A dosimetric comparison of three plans in simultaneous integrated boost intensity-modulated radiotherapy in cervical esophageal carcinoma undergoing prophylactic lymphatic irradiation |
| Received:April 20, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.01.012 |
| KeyWords:Esophageal neoplasms Intensity-modulated radiotherapy Simultaneous integrated boost Lymphatic irradiation,prophylactic Dosimetry |
| FundProject: |
| Author Name | Affiliation | | QIU Guo-qin | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | ZHU Cheng-long | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | DU Xiang-hui | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China | | CHEN Jian-xiang | Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China |
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| Abstract:: |
| Objective To evaluate the optimized simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) plans in cervical esophageal carcinoma underwent prophylactic lymphatic irradiation. Methods Six patients with cervical esophageal carcinoma were studied. The gross tumor volume (GTV) and clinical target volume (CTV) (including bilateral mid-lower neck and supraclavicular lymph drainage regions, upper mediastinal lymph drainage regions) were delineated on sim-CT images, GTV and CTV were uniformly expanded by 5 mm to create PGTV and PTV. Five fields(5F),7F and 9F SIB-IMRT plans were designed. The prescribed doses to PGTV and PTV were 66 Gy and 60 Gy in 30 fractions respectively. The parameters of dose-volume histograms in three groups planning were compared. Results The values of conformity index(CI) of PGTV were 0.56, 0.62 and 0.69 (F=6.22,P<0.01), the V66 with 88.24%,95.03% and 94.91%(F=4.39,P<0.05)and D95 with 6539.67,6601.83 and 6602.00 cGy (F=4.46,P<0.05) in 5F,7F and 9F SIB-IMRT plans. The values of CI, V66 and D95 of PTV were 0.80,0.85 and 0.87 (F=11.29,P<0.01), with 91.64%, 94.05% and 95.06% (F=4.10,P<0.05) and with 5934.00,5987.17 and 6006.33 cGy (F=4.01,P<0.05). The values of maximal dose of spinal cord were 4707.17,4497.83 and 4357.00 cGy(F=11.26,P<0.01)in 5F,7F and 9F SIB-IMRT plans. The values of all dosimetic parameters about PGTV and PTV were same in 7F and 9F SIB-IMRT plans(all P>0.05). Conclusion 7F-SIB-IMRT plan is best one scheme for cervical esophageal carcinoma underwent prophylactic lymphatic irradiation. |
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