| HAN Da-li,ZHANG Gui-fang,FU Zheng,et al.Dosimetric comparison of simulation treatment planning for thoracic esophageal carcinoma patients in contouring biological tumor volume with FLT and FDG PET-CT[J].Chinese Journal of Radiological Medicine and Protection,2011,31(1):41-45 |
| Dosimetric comparison of simulation treatment planning for thoracic esophageal carcinoma patients in contouring biological tumor volume with FLT and FDG PET-CT |
| Received:April 27, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.01.011 |
| KeyWords:Esophageal neoplasms Radiotherapy Tomography Positron emission Biological tumor volumes Dosimetry |
| FundProject:山东省医药卫生科技发展计划青年基金(2009QZ028);山东省自然科学基金(ZR2009CM131) |
| Author Name | Affiliation | | HAN Da-li | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | ZHANG Gui-fang | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | FU Zheng | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | LU Jie | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | ZHONG Xiao-jun | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | ZHAO Shu-qiang | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | WANG Xiao-hui | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | HOU Qing-zhen | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | YU Yong-hua | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China | | YU Jin-ming | Department of Radiation Oncology, Shandong Cancer Hospital, Key Laboratory of Radiation Oncology in Shandong, Jinan 250117, China |
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| Abstract:: |
| Objective To investigate a feasibility of treatment planning in thoracic esophageal carcinoma with 3-deoxy-3-fluorothymidine (FLT) PET-CT and to compare with fluorodeoxyglucose(FDG) PET-CT based on dosimetric analysis. Methods Twenty-two patients with esophageal squamous cell carcinoma detected by FLT and FDG PET-CT were enrolled. The gross tumor volumes(GTV), clinical target volume(CTV) and planning target volume (PTV) were delineated using treatment planning system of Philips Pinnacle3 based on the optimal threshold of FLT and FDG PET-CT respectively, and to make two groups simulation treatment planning. The parameters of dose-volume histograms in two groups planning were compared in the similar direction and ensuring prescribed dose line surround 95% target volume. Results The values of GTV, CTV and PTV in FLT PET-CT planning were less than those of FDG, that was 29.03 cm3 ∶33.05 cm3(t=-2.62,P<0.05), 244.22 cm3 ∶257.01 cm3(t=-3.53,P<0.05) and 351.29 cm3 ∶379.85 cm3(t=-4.01,P<0.05),respectively. There were no significantly difference in conformity index and homogeneity index in two planning, that was 0.74 ∶0.72(t=0.89,P>0.05) and 1.09 ∶1.11(t=1.41,P>0.05),respectively. The values of V20 of bilateral lung, V40 of heart and maximal dose received by spinal cord in two planning were not significantly yet(t=-1.60,-1.55,all P>0.05). While, the values in mean lung dose, V5, V10, V30, V40 and V50 of bilateral lung, mean heart dose, and V30 of heart in FLT PET-CT planning were significant lower than those of FDG(t=-5.442--2.637,all P<0.05). Conclusions Compared with FDG, FLT PET-CT based treatment planning brings potential benefits for lungs and heart. |
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