| YAN Dan-fang,YAN Sen-xiang,YANG Jin-song,SUN Xiao-li,LU Zhong-jie.Therapeutic effects and quality of life in 37 glioma patients with postoperative intensity-modulated radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2010,30(6):721-724 |
| Therapeutic effects and quality of life in 37 glioma patients with postoperative intensity-modulated radiotherapy |
| Received:April 20, 2010 |
| DOI： |
| KeyWords:Glioma Intensity-modulated radiotherapy Quality of life Cognitive function Memory disorder |
| FundProject: |
| Author Name | Affiliation | E-mail | | YAN Dan-fang | Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China | | | YAN Sen-xiang | Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China | yansenxiang@zju.edu.cn | | YANG Jin-song | Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China | | | SUN Xiao-li | Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China | | | LU Zhong-jie | Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China | |
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| Abstract:: |
| Objective To evaluate treatment outcomes and quality of life (QOL) in glioma patients treated with postoperative intensity-modulated radiotherapy (IMRT), and to explore the possible clinical factors of affecting QOL. Methods From 2007 to 2009, 37 patients with low or high grade glioma were analyzed retrospectively. All patients were operated by tumor resection below microscopy. IMRT began at 2-4 week postoperation with 2.0 Gy/fractior, 5 fractions/week and to shrink portal and to add dose to 50-60 Gy/25-30 fractions after 40-50 Gy. The gross tumor volume (GTV) was defined as preoperation T2WI MRI high sign area and postoperation tumor cavity for low grade glioma, and with preoperation T1WI MRI enhanced abnormity area and postoperation tumor cavity for high grade glioma. The clinical target volume (CTV) was defined as GTV with a margin of 1.5 cm for low grade glioma and a margin of 2.5 cm for high grade glioma, the planning target volume (PTV) with CTV plus 0.4 cm margin for setup errors according to the European Organization for Research and Treatment of Cancer (EORTC). The treatment outcomes and QOL were assessed. Results The half-year and one-year survival rates for all the patients were 100% and 79.2%, respectively. The median progression-free survival time was 10 months. The main side-responses after postoperative IMRT were fatigue and mild memory decline or cognitive disabilities, which were radiation dose-dependent. Conclusions Postoperative IMRT is an effective and safe modality of therapy for glioma patients. |
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