| LIN Xiu-tong,SUN Tao,WANG Chuan-dong,YIN Yong,LIU Tong-hai,CHEN Jin-hu.Dosimetric comparison of fixed field intensity modulated radiation therapy and RapidArc volumetric modulated arc therapy in treatment of multiple intracranial metastases[J].Chinese Journal of Radiological Medicine and Protection,2010,30(5):585-590 |
| Dosimetric comparison of fixed field intensity modulated radiation therapy and RapidArc volumetric modulated arc therapy in treatment of multiple intracranial metastases |
| Received:January 06, 2010 |
| DOI： |
| KeyWords:Intensity-modulated Arc radiotherapy Intensity modulated radiotherapy Multiple intracranial metastases Dosimetry |
| FundProject: |
| Author Name | Affiliation | E-mail | | LIN Xiu-tong | Shandong Tumor Hospital, Jinan 250117, China | | | SUN Tao | Shandong Tumor Hospital, Jinan 250117, China | | | WANG Chuan-dong | 山东潍坊安丘市人民医院放疗科 | | | YIN Yong | Shandong Tumor Hospital, Jinan 250117, China | yinyongsd@yahoo.com.cn | | LIU Tong-hai | Shandong Tumor Hospital, Jinan 250117, China | | | CHEN Jin-hu | Shandong Tumor Hospital, Jinan 250117, China | |
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| Abstract:: |
| Objective To evaluate the performace of fixed field Intensity modulated radiation therapy (IMRT) and RapidArc in the radiotherapy for multiple intracranial metastases. Methods The clinical data of 10 patients with multiple intracranial metastases, 8 male and 2 female, aged 65-73, were used to design 3 plans:fixed field IMRT, RapidArc with single Arc (RA1), and RapidArc with double Arc (Arc 2). Dose-volume-histogram analysis was used to compare dose results, monitor unit, and delivery time. Results All 3 plans met the clinical requirements. The best target conformity and homogeneity were observed in the RA2 plan (Z=-2.803,-2.904,P<0.05) and there were no statistical differences between the IMRT plan and RA1 plan. The maximum doses to the lens, eyes, and brainstem of the two RapidArc plans were all significantly lower than those of the IMRT plan(Z=-2.803--2.191,P<0.05), and the maximum dose to the optic nerves of the RA2 plan was significantly lower than that of the IMRT plan (Z=-2.293,-2.701,P<0.05). Compared with the IMRT plan, the average monitor units of the RA1 and RA2 plans were reduced by 29% and 24%, respectively, and the delivery time of these plans were significantly shorter by 84% and 69%, respectively. Conclusions Compared to the IMRT plan, RapidArc plans with single or double Arcs show similar or better effects in the target dose distribution, reduction of irradiation doses on organs at risk and,moreover, significant decrease of the monitor units and delivery time. |
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