| WANG Chuan-gao,WANG Li,ZHOU Ping-kun,et al.Radiological protection effect of vanillin derivative VND3207 against radiation-induced cytogenetic damage in mouse bone marrow cells[J].Chinese Journal of Radiological Medicine and Protection,2010,30(5):558-560 |
| Radiological protection effect of vanillin derivative VND3207 against radiation-induced cytogenetic damage in mouse bone marrow cells |
| Received:February 03, 2010 |
| DOI： |
| KeyWords:Vanillin derivative γ-ray Polychromatophilic erythroblasts micronuclei Chromosome aberration Mitotic index Radioprotective agent |
| FundProject:国家自然科学基金杰出青年基金(C30825011) |
| Author Name | Affiliation | E-mail | | WANG Chuan-gao | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | | | WANG Li | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | | | ZHOU Ping-kun | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | | | WANG Zhong-wen | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | | | HU Yong-zhe | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | | | JIN Hai-ming | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | | | ZHANG Xue-qing | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | | | CHEN Ying | Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,Beijing 100850, China | yingchen29@yahoo.com.cn |
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| Abstract:: |
| Objective To study the protection of vanillin derivative VND3207 on the cytogenetic damage of mouse bone marrow cell induced by ionizing radiation. Methods BALB/c mice were randomly divided into five groups:normal control group, 2 Gy dose irradiation group, and three groups of 2 Gy irradiaiton with VND3207 protection at doses of 10, 50 and 100 mg/kg, respectively. VND3207 was given by intragastric administration once a day for five days. Two hours after the last drug administration, the mice were irradiated with 2 Gy γ-rays. The changes of polychromatophilic erythroblasts micronuclei (MN), chromosome aberration (CA) and mitosis index (MI) of mouse bone marrow cells were observed at 24 and 48 h after irradiation. Results Under the protection of VND3207 at the dosages 10, 50, 100 mg/kg, the yields of poly-chromatophilic erythroblasts MN and CA of bone marrow cells were significantly decreased(t=2.36-4.26,P<0.05), and the marrow cells MI remained much higher level compared with the irradiated mice without drug protection(t=2.58,2.01,P<0.05). The radiological protection effect was drug dose-dependent, and the administration of VND3207 at the dosage of 100 mg/kg resulted in reduction by 50% and 65% in the yields of MN and CA, respectively. Conclusions VND3207 had a good protection effect of on γ-ray induced cytogentic damage of mouse bone marrow cells. |
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