| WANG Jing,JING Hong-mei,WANG Ji-jun,et al.Diagnostic value of (1,3)-β-D-glucan assay and galactomannan test for invasive fungal infection in patients of acute radiation sickness[J].Chinese Journal of Radiological Medicine and Protection,2010,30(5):527-530 |
| Diagnostic value of (1,3)-β-D-glucan assay and galactomannan test for invasive fungal infection in patients of acute radiation sickness |
| Received:April 13, 2010 |
| DOI： |
| KeyWords:Acute radiation sickness(ARS) Invasive fungal infection(IFI) (1, 3)-β-D-glucan Galactomannan |
| FundProject:卫生部公益型行业科研基金项目 (200802027) |
| Author Name | Affiliation | E-mail | | WANG Jing | Department of Hematology, Peking University Third Hospital, Beijing 100191,China | | | JING Hong-mei | Department of Hematology, Peking University Third Hospital, Beijing 100191,China | | | WANG Ji-jun | Department of Hematology, Peking University Third Hospital, Beijing 100191,China | | | LIU Yan | Department of Hematology, Peking University Third Hospital, Beijing 100191,China | | | ZHAO Wei | Department of Hematology, Peking University Third Hospital, Beijing 100191,China | | | NING Yong-zhong | 北京大学第三医院血液科, 检验科 | | | ZHANG Jie | 北京大学第三医院血液科, 检验科 | | | KE Xiao-yan | Department of Hematology, Peking University Third Hospital, Beijing 100191,China | xiaoyank@yahoo.com |
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| Abstract:: |
| Objective To investigate the diagnostic values of (1,3)-β-D-glucan (G) and galactomannan (GM) for invasive fungal infection (IFI) in patients of acute radiation sickness (ARS). Methods Samples of periogeral blood, pharyngeal secretion, urine, and feces were collected from 316 patients with ARS and suspected to suffer from IFI, 192 males and 124 females, aged 60.50(1-96), with the underlying diseases of blood or respiration systems. Platelia Aspergillus EIA kit was used to detect the plasma BG (G test), and ELISA was used to detect the serum GM (GM test). Fungal culture and bacterial culture were performed. Results The positive rates of G test, GM test, and fungal culture were 36.33%, 35.84%, and 34.18% respectively, but the positive rate of fungal culture of blood sample was 1/316 only. Pearson correlation analysis showed that G test,GM test and fungal culture test were positively correlated with IFI clinical diagnosis respectively(χ2=0.564,0.357,0.727,P<0.05). Conclusions Easy to operate, rapid, and highly sencitive, G test and GM test can be used as adjunctive methods for early IFI diagnosis in ARS patients. |
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