| LIANG Li,ZHANG Shu-lan,JIA Ting-zhen,LIU Qing-jie,MA Li-wen,SU Xu,ZHANG Zhao-hui,QIN Bin,CHEN Sen,WANG Wen-xue.Follow-up of victim exposed in uterus 16 yearsafter Xinzhou radiation accident[J].Chinese Journal of Radiological Medicine and Protection,2010,30(5):520-522 |
| Follow-up of victim exposed in uterus 16 yearsafter Xinzhou radiation accident |
| Received:April 13, 2010 |
| DOI： |
| KeyWords:Radiation injury Radiation exposure in uterus Growth and development Intelligence development |
| FundProject: |
| Author Name | Affiliation | E-mail | | LIANG Li | Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hosptial, Beijing, 100191, China | | | ZHANG Shu-lan | Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hosptial, Beijing, 100191, China | | | JIA Ting-zhen | Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hosptial, Beijing, 100191, China | jiatingzhen@sina.com | | LIU Qing-jie | 中国疾病预防控制中心辐射防护与核安全医学所 | | | MA Li-wen | Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hosptial, Beijing, 100191, China | | | SU Xu | 中国疾病预防控制中心辐射防护与核安全医学所 | | | ZHANG Zhao-hui | Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hosptial, Beijing, 100191, China | | | QIN Bin | 中国疾病预防控制中心辐射防护与核安全医学所 | | | CHEN Sen | Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hosptial, Beijing, 100191, China | | | WANG Wen-xue | Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hosptial, Beijing, 100191, China | |
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| Abstract:: |
| Objective To observe and study the late effects of intrauterine exposure to irradiation. Methods A 16-year-old girl, borne by a woman exposed to 60Co irradiation during the Xinzhou radiation accident 16 years ago underwent inquiry, general medical examination. Conventional chromosome aberration analysis and fluorescence in situ hybridization (FISH) were used to examine non-stability and stability chromosome aberrations, and China revised Wechsler Intelligence Scale for Children (C_WISC) was used to detect IQ level. Results Inquiry revealed no history of carcinoma and no family history of hereditary diseases. The girl often caught cold when she was a child, but she hadn’t any other diseases. Menarche occurred when she was 12 years old, and she had not suffered from dysmenorrhea. Her development of body frame constitution was normal. She could not carry out addition and subtraction, but she could make simple verbal communication, writing and even reciting text. The results of the routine lab examination were within the normal range. Unstable chromosome aberrations were not shown, and the chromosome translocation rate was 2.3%. The dose that induced the chromosome injury was deduced as 0.81 Gy. The biological dose of the radiation that she was exposed to was inferred to be 1.85 Gy when she was in ther mothers uterus. Ultrasonic sound showed nodular goiter and no malignant change. Chinas revised Wechsler Intelligence Scale for Children (C_WISC) test results showed that speech, operation and full-scale IQ was 51, 50, and 46 respectively. The total intelligence was better than 0.01%, and worse than 99.90% of the population. Conclusions Exposure in utero does not affect the body frame constitution development after birth of the fetus, but mental retardation is clear. No evidence of any tumor can be found for the children exposed to radiation before their birth. |
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