| LU Xue,ZHAO Hua,LIANG Li,et al.Retrospective dose estimation for individuals exposed to accidental exposure in uterus with fluorescence in situ hybridization[J].Chinese Journal of Radiological Medicine and Protection,2010,30(5):513-515 |
| Retrospective dose estimation for individuals exposed to accidental exposure in uterus with fluorescence in situ hybridization |
| Received:January 06, 2010 |
| DOI： |
| KeyWords:Xinzhou radiation accident In-uterus exposure Retrospective dose estimation Fluorescence in situ hybridization |
| FundProject:国家自然科学基金(30570551, 30870749);卫生行业科研专项(200802018) |
| Author Name | Affiliation | E-mail | | LU Xue | National Institute for Radiation Protection, Chinese Center for Disease Control and Prevention, Beijing 100088,China | | | ZHAO Hua | National Institute for Radiation Protection, Chinese Center for Disease Control and Prevention, Beijing 100088,China | | | LIANG Li | 北京大学第三医院 | | | ZHANG Shu-lan | 北京大学第三医院 | | | FENG Jiang-bin | National Institute for Radiation Protection, Chinese Center for Disease Control and Prevention, Beijing 100088,China | | | ZHANG Zhao-hui | 北京大学第三医院 | | | CHEN De-qing | National Institute for Radiation Protection, Chinese Center for Disease Control and Prevention, Beijing 100088,China | | | MA Li-wen | 北京大学第三医院 | | | JIA Ting-zhen | 北京大学第三医院 | | | LIU Qing-jie | National Institute for Radiation Protection, Chinese Center for Disease Control and Prevention, Beijing 100088,China | qjliu@nirp.cn |
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| Abstract:: |
| Objective To reconstruct the absorbed dose for the individual who was accidentally exposed in uterus 16 years ago. Methods Peripheral blood samples were taken from the victim and her mother. The dicentric and centric ring chromosome aberrations were analyzed with conventional method, the micronucleus was observed with cytokinesis-block micronucleus method, and fluorescence in situ hybridization (FISH) with chromosomes 1, 2 and 4 painting probes were used for translocation detection. Dose was estimated according to the standard dose-response curves previously established. Results No unstable chromosome aberrations and normal micronucleus frequencies were observed in two persons 16 years after the accident. Against the established dose-response curves with FISH, the doses to the mother and her daughter were 0.76 Gy (95% CI 0.41-1.00 Gy) and 0.61 Gy (95% CI 0.44-0.86 Gy), respectively. Because the biological dose estimated for the mother 1 month after the accident was 2.30 Gy (95% CI 2.07-2.50 Gy), the dose correction factor was 3.03 for dose estimation 16 years later. The estimated dose in uterus to the victim was 1.85 Gy (95% CI 1.33-2.61 Gy). Conclusions The estimated dose to the individual accidentally exposed in uterus 16 years ago can be obtained according to the dose correction factor of the mother with FISH method. |
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