| SUN Xiao-jiang,XU Ya-ping,JI Yong-ling,LIU Jin-shi,JIANG You-hua,MA Sheng-lin,MAO Wei-min.Prognosis analysis of esophageal carcinoma patients with tumor loco-regional recurrence after curative surgery[J].Chinese Journal of Radiological Medicine and Protection,2010,30(3):333-335 |
| Prognosis analysis of esophageal carcinoma patients with tumor loco-regional recurrence after curative surgery |
| Received:January 23, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2010.03.028 |
| KeyWords:Esophageal cancer Recurrence after surgery Radiotherapy Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | SUN Xiao-jiang | Zhejiang Cancer Hospital, Hangzhou 310022, China | | | XU Ya-ping | Zhejiang Cancer Hospital, Hangzhou 310022, China | xuyaping1207@gmail.com | | JI Yong-ling | Zhejiang Cancer Hospital, Hangzhou 310022, China | | | LIU Jin-shi | 310022 杭州, 浙江省肿瘤医院胸外科 | | | JIANG You-hua | 310022 杭州, 浙江省肿瘤医院胸外科 | | | MA Sheng-lin | Zhejiang Cancer Hospital, Hangzhou 310022, China | | | MAO Wei-min | 310022 杭州, 浙江省肿瘤医院胸外科 | |
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| Abstract:: |
| Objective To evaluate the outcome of radiotherapy for recurrent esophageal cancer after surgery and to determine the prognostic factors.Methods From Jan 2004 to Dec 2009, 93 patients of esophageal carcinoma with loco-regional recurrence as the first site of failure after surgery were retrospectively reviewed. Kaplan-Meier method was used to analyze the survival.Logrank test was used to evaluate the difference between the groups.Multivariate survival analysis was conducted using a Coxproportional hazard regression model with a backward stepwise procedure. Results The overall survival rates at 1, 2 and 3 years were 40.9%, 10.1% and 6.7%,respectively,but with a median survival time of 11.0 months(95%CI 9.4-12.6).In univariate analysis, age,PS, radiation dose and retreatment methods were independent prognostic factors. In multivariate analysis, only radiation dose and retreatment methods were independent prognostic factors for overall survival.Conclusions The prognosis of patients with post-operative loco-regional recurrence of esophageal cancer is poor. However, a long-term survival maybe expected by definitive chemoradiotherapy. |
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