| XI Lei,XIA De-hong,SHEN Wei-sheng,et al.Intervention of Astragalus membranaceus on radioactive lung injuries and influence on TNF-α and ET expression[J].Chinese Journal of Radiological Medicine and Protection,2010,30(3):327-329 |
| Intervention of Astragalus membranaceus on radioactive lung injuries and influence on TNF-α and ET expression |
| Received:July 07, 2009 |
| DOI：10.3760/cma.j.issn.0254-5098.2010.03.026 |
| KeyWords:Radiotherapy Astragalus membranaceus Lung injuries Radioprotection TNF-α Endothelin |
| FundProject:江苏省中医药局中医药科研项目(HZ07092) |
| Author Name | Affiliation | | XI Lei | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China | | XIA De-hong | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China | | SHEN Wei-sheng | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China | | ZHOU Jian-bo | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China | | SHU Zhong-qin | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China | | YU Bo | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China | | HOU Xin-heng | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China | | WANG Ke | Jiangyin Hospital of Medical College, Southeast University, Jiangyin 214400, China |
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| Abstract:: |
Objective To observe the lung protection of Astragalus membranaceus against radiotherapy to intermediate-stage and terminal thoracic neoplasm, and its influence on TNF-α and ET expression.Methods The patients with intermediate-stage and terminal thoracic neoplasm under radiotherapy were divided into a treatment group and a control group. Patients in the treatment group took 10 ml of Asragalus membranaceus twice a day, for consecutive 6 months from the beginning of radio therapy. TNF-α and ET in the plasma were measured before and after the radiotherapy. The clinical symptom, iconographic changes and lung diffusion were observed from the 15th day of radiotherapy. Results The TNF-α and ET in plasma after the radiotherapy were (2.48±0.75) ng/ml and (69.32±23.03) pg/ml for the treatment group, and (5.12±1.01) ng/ml and (97.87±37.83) pg/ml for the control group with the statistial difference ( =7.49,6.57,P<0.001). The decrease of CO diffusion 5 and 10 months after the radiotherapy in the treatment group was statistically different compared with that in the control group (=3.98,3.78,P<0.05). There was a statistical difference of the incidence of acute radiation pneumonitis and pulmonary fibrosis between these two groups (P<0.05).Conclusions Astragalus membranaceus could inhibit the excess expression of TNF-α and ET in plasma and reduce the deterioration of diffusion after radiotherapy, so that it can be used for intervention of lung injuries from radiotherapy. |
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