| PAN Chun-xia,SHENG Xiu-gui,ZHANG Xiao-ling,et al.Observation of hyperfractional integrated intracavitary brachytherapy on efficacy and complications in patients with middle and advanced squamous cell carcinoma of the cervix[J].Chinese Journal of Radiological Medicine and Protection,2010,30(3):324-326 |
| Observation of hyperfractional integrated intracavitary brachytherapy on efficacy and complications in patients with middle and advanced squamous cell carcinoma of the cervix |
| Received:September 04, 2009 |
| DOI：10.3760/cma.j.issn.0254-5098.2010.03.025 |
| KeyWords:Cervix neoplasm Intracavitary brachytherapy/ Integrated intracavitary brachytherapy Hyperfactionation Efficacy Complications |
| FundProject:山东省科技攻关项目(2009GG10002010) |
| Author Name | Affiliation | E-mail | | PAN Chun-xia | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | | | SHENG Xiu-gui | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | JNSXG@hotmail.com | | ZHANG Xiao-ling | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | | | DU Xue-lian | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | | | LI Qing-shui | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | | | MA Zhi-fang | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | | | MIAO Hua-qin | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | | | MA Yue-bing | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | | | LIU Nai-fu | Department of Gynecologic Oncology, Shandong Cancer Hospital, Jinan 250117, China | |
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| Abstract:: |
| Objective To observe and cpmpare the efficacy and complications of hyperfractional integrated intracavitary brachtherapy in middle-advanced squamous-cell carcinoma with the traditional brachytherapy. Methods In the observed group,328 patients with cervical cancer received hyperfractional integrated intracavitary after loading therapy between Jan 2004 and Jan 2005 were selected. The dose of point A was 2.5 Gy-3.0 Gy/ fraction,2 fractions per week,and the total dose of reference point A was 49.8 Gy in stage Ⅱb, 52.6 Gy in stage Ⅲb.In the control group, 331 cases treated with traditional afterloading brachytherapy between Jan 2002 and Dec 2003 were selected. The dose of point A was 5.0~7.0 Gy /fraction,1 fraction per week, and the total dose of point A was 50.1 Gy in stage Ⅱb, 53.5 Gy in stage Ⅲb. In vitro irradiation began at the same time with the intracavitary brachytherapy. The whole pelvic was irradiated with 15 MV X-rays.Results In the observed group, the recent control rate of stage Ⅱb was 97.2%(104/107), 94.1%(208/221) for stage Ⅲb. The 3-year survival rate was 80.5% (264/328), and the 5-year survival rate was 68.6% (225/328).The complication rate was 5.2% (17/328) for cystitis, 14.6%(48/328) for proctitis. Out of 331 cases in control group, the recent control rate of stage Ⅱb was 95.4%(103/108),92.8%(207/223) for stage Ⅲb. The 3-year survival rate was 75.2%(249/331),the 5-year survival rate was 62.5%(207/331).The complication rate was 13.3%(44/331) for cystitis,and 32.3%(107/331) for proctitis.Conclusions Compared with combination of traditional brachytherapy and external radiotherapy, combination of hyperfractional integrated brachtherapy therapy and external radiotherapy has no significant improvement for recent control rate and long-term survival rate,but could reduce the complication rates of cystitis and proctitis. |
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