| CUI Yan-li,ZHU Shu-chai,LIU Zhi-kun,SU Jing-wei,LI Juan,SHEN Wenbin,WANG Yu-xiang.Analysis of acute radiation injury in non-small cell lung cancer treated by three-dimensional conformal radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2010,30(3):320-323 |
| Analysis of acute radiation injury in non-small cell lung cancer treated by three-dimensional conformal radiotherapy |
| Received:July 21, 2009 |
| DOI：10.3760/cma.j.issn.0254-5098.2010.03.024基金项目:国家自然科学基金(30870743);河北省自然科学基金(C2005000802)作者单位:050011 石家庄,河北医科大学第四医院放疗科［崔彦莉(现在邢台市人民医院放疗科)、祝淑钗、刘志坤、苏景伟 、李娟、 沈文斌 、王玉祥］ |
| KeyWords:Non-small cell lung cancer Three dimensional conformal radiotherapy Radiation induced injury Dose-volume histogram(DVH) |
| FundProject: |
| Author Name | Affiliation | E-mail | | CUI Yan-li | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011 China | | | ZHU Shu-chai | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011 China | sczhu@heinfo.Net | | LIU Zhi-kun | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011 China | | | SU Jing-wei | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011 China | | | LI Juan | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011 China | | | SHEN Wenbin | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011 China | | | WANG Yu-xiang | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011 China | |
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| Abstract:: |
| Objective To analyze the influencing factors with radiation induced injury of non-small cell lung cancer (NSCLC) treated by three-dimensional conformal radiotherapy, in order to supply the reference criteria for optimize the treatment planning of NSCLC,further to improve the local control rate and quality of life of NSCLC patitents. Method From Aug 2000 to Dec 2004, 107 NSCLC patients received three-dimensional conformal radiotherapy were enrolled in this study. In all the patients, 48 patients accepted three dimensional conformal radiotherapy (3D-CRT), the other 59 patients accepted conventional radiotherapy (CRT) before later-course of 3D-CRT. All of the patients received the prescription dose between 60-78Gy and the median dose 66Gy. Results In the 107 patients, the rate of radiation induced injury was 62.6%, and the rate of ≥2 grade was 38.3%. 23 cases were classified in grade 2, 14 cases in grade 3, 4 cases in grade 4.Univariate analysis showed chronic obstructive pulmonary disease, number of beams field, lung mean dose, lung V5-V40 were important influencing factors on radiation induced injury. Further more, lung mean dose, lung V20 and chronic obstructive lung disease were likely to be the independent factors of radiation induced injury by Logistic model.Conclusions lung mean dose, chronic obstructive lung disease and lung V20 were the independent influencing factors on irradiated induced injury. |
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