| HU Ke,PANG Ting-tian,YANG Bo,et al.Dosimetric analysis of preoperative three-dimensional conformal and preoperative intensity modulated radiotherapy for rectal cancer[J].Chinese Journal of Radiological Medicine and Protection,2010,30(3):310-313 |
| Dosimetric analysis of preoperative three-dimensional conformal and preoperative intensity modulated radiotherapy for rectal cancer |
| Received:March 03, 2010 |
| DOI：10.3760/cma.j.issn.0254-5098.2010.03.021 |
| KeyWords:Rectal carcinoma Preoperative radiotherapy Three-dimensional conformal radiotherapy Intensity-modulated radiotherapy Dosimetry |
| FundProject: |
| Author Name | Affiliation | | HU Ke | Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China | | PANG Ting-tian | Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China | | YANG Bo | Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China | | ZHANG Fu-quan | Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China | | QIU Jie | Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China |
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| Abstract:: |
| Objective To compare the dose distribution of the three-dimensional conformal radiotherapy (3D- CRT) and 5-field or 7-field intensity modulated radiation therapy (IMRT),and to explore the value of IMRT in preoperative radiotherapy for rectal cancer. Methods Ten rectal cancer patients treated with preoperative combination radiotherapy and chemotherapy were enrolled in this study. 3D- CRT plan and the 5-field or 7-field IMRT plans were performed for each patient. The conformal index (CI), heterogeneity index (HI) of the planning target volume (PTV) and the dose of normal organs of 3D- CRT plan (3D- CRTp) and the 5-field or 7-field IMRT plans (IMRT5fp or IMRT7fp) were analyzed with the dose-volume histogram. Results The CI values of PTV were 0.91,0.87 and 0.78 in IMRT7fp,IMRT5fp and 3D- CRT but with IMRT7fp > IMRT5fp > 3D- CRTp (t=-5.69、-8.91,P<0.01), respectively. The HI values of PTV were 1.09,1.08 and 1.05 in IMRT5fp,IMRT7fp and 3D- CRTp but with IMRT5fp > IMRT7fp > 3D- CRTp (t=3.41、-6.89,P<0.01), respectively. The ratio of dose volume were 0.08,0.10 and 0.19 (t=2.79、3.52,P<0.05) in IMRT7fp,IMRT5fp and 3D- CRTp on the small intestine V50,with 0.07,0.10 and 0.19 (t=2.58、3.40,P<0.05) in IMRT7fp,IMRT5fp and 3D- CRTp on the bladder V50 and 0.01,0.01 and 0.05 (t=3.00、3.17,P<0.01) in IMRT7fp,IMRT5fp and 3D- CRTp on the femoral head V45. The ratio of dose volume were 0.31 and 0.38 (t=3.91,P<0.01) in IMRT7fp and IMRT5fp on the bone marrow V50, with 0.07 and 0.10 in IMRT7fp and IMRT5fp on bladder V45. Conclusions IMRT plan is superior to 3D- CRT plan in dose conformal degrees of PTV with preoperative radiotherapy of rectal cancer and can significantly protect the normal tissues. The 7-field IMRT plan might be the optimal plan for dose conformal degree and dose uniformity compared with 5-field IMRT. |
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