| ZHAO Zhen-hu,WANG Ning,LI Ming,et al.Clotting mechanism in beagles irradiated by 4.5 Gy γ-rays[J].Chinese Journal of Radiological Medicine and Protection,2010,30(3):256-259 |
| Clotting mechanism in beagles irradiated by 4.5 Gy γ-rays |
| Received:December 24, 2009 |
| DOI：10.3760/cma.j.issn.0254-5098.2010.03.006 |
| KeyWords:Thrombelastogram Platelet aggregation rate Blood clotting Cytokines |
| FundProject:国防科工委"十一五"核科学基础研究重点项目(A3620060130) |
| Author Name | Affiliation | E-mail | | ZHAO Zhen-hu | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | WANG Ning | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | LI Ming | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | XING Shuang | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | HUANG Hai-xiao | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | OU Hong-ling | 第二炮兵总医院 | | | XIONG Guo-lin | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | ZHAO Yan-fang | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | XIE Ling | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | WANG Jin-xiang | 苏州大学医学部 | | | MIAO Jing-cheng | 苏州大学医学部 | | | ZHU Nan-kang | 苏州大学医学部 | | | ZHANG Xue-guang | 苏州大学医学部 | | | LUO Qing-liang | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | CONG Yu-wen | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | congyw@bmi.ac.cn |
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| Abstract:: |
| Objective To explore the clotting mechanism in beagles irradiated by 4.5 Gy γ-rays after treatment with supportive care, or supportive care and combined cytokines. Methods Sixteen beagles were divided into irradiation control group, Supportive care group and combined cytokines treatment group. Platelet aggregation test, thrombelastography (TEG) and the time measurement were analyzed in vitro . Results In irradiation group and supportive care group, the platelet aggregation rates in beagles were decreased markedly and the k value of TEG was increased 7 d post-irradiation, while those indexes in combined cytokines treatment group changed little. At 14 d post-irradiation, each parameter of TEG in irradiated group changed obviously. The values of r, k, r k and M were elevated significantly, clotting time and the maximum coagulation time of thrombus delayed, the Ma value was decreased markedly, and the maximum elasticity amplitude of thrombus was diminished. All parameters in combined cytokines treatment group were better than those in supportive care group. The thrombin time was prolonged obviously in irradiated group 14 d post-irradiation, while the thrombin time was the longest at 2-3 weeks post irradiation in supportive care group and combined cytokines treatment group (P>0.05). Conclusions Cytokines could improve the platelet aggregation and the blood clotting functions of beagles suffering from acute radiation sickness. |
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