| WANG Zhen-hua,ZHAO Wei-ping,LIU Qing,et al.Protective effect of Ginsenoside Rh2 on X-ray radiation damage in mice[J].Chinese Journal of Radiological Medicine and Protection,2010,30(2):143-146 |
| Protective effect of Ginsenoside Rh2 on X-ray radiation damage in mice |
| Received:March 06, 2009 |
| DOI： |
| KeyWords:Ginsenoside Rh2 X-rays Radiation protection |
| FundProject:国家自然科学基金重点项目(10835011); 国家自然科学基金面上项目(10675151); 中国博士后科学基金(20080440740) |
| Author Name | Affiliation | E-mail | | WANG Zhen-hua | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China | | | ZHAO Wei-ping | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China | | | LIU Qing | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China | | | LI Ning | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China | | | ZHANG Hong | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China | zhangh@impcas.ac.cn |
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| Abstract:: |
| Objective To evaluate the radioprotective effects of ginsenoside Rh2 on mice in response to X-ray irradiation.Methods Mice were initially subjected to whole body X-ray irradiation with total doses of 4 Gy at a dose rate of 0.5 Gy/min. Then, the mice were intragastrically administered instantly with 5, 10 or 20 mg/kg ginsenoside Rh2.At 24 h post-irradation, the damage to bone marrow cells as well as DNA fragments in peripheral blood leukocytes (PBLs) were assessed by micronucleus (MN) test and comet assay, respectively. The splenic lymphocyte transformation mediated by concanavalin (ConA) and lipopolysaccharide (LPS) was measured by MTT colorimetric method. Results The present study demonstrated that Ginsenoside Rh2 significantly decreased the DNA damage degree in PBLs and MN formation in bone marrow polychromatic erythrocytes in a concentration dependent manner. Also, the treatment with Ginsenoside Rh2 enhanced the splenic lymphocyte transformation activities.Conclusions The administration of Ginsenoside Rh2 shortly after irradiation is able to prevent the mice from the genotoxicity and immunotoxicity induced by X-rays and, probably, offer a promising strategy for both protection and treatment of radiation injuries. |
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