| ZHANG Zi-cheng,XU Jin,LI Bao-sheng,YIN Yong,HUANG Yong,YANG Feng-chang,LI Hong-sheng,SUN Hong-fu,CHEN Jin-hu,LIU Bo.Risk factors for computed tomography grade of radiation-induced lung injury in lung cancer treated with three-dimensional conformal radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2010,30(1):54-57 |
| Risk factors for computed tomography grade of radiation-induced lung injury in lung cancer treated with three-dimensional conformal radiotherapy |
| Received:February 28, 2009 |
| DOI： |
| KeyWords:Lung cancer Three-dimensional conformal radiotherapy Radiation-induced lung injury CT grade |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHANG Zi-cheng | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | XU Jin | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | LI Bao-sheng | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | baoshli@yahoo.com | | YIN Yong | 山东省肿瘤医院放疗科, 物理室 | | | HUANG Yong | 山东省肿瘤医院放疗科, CT室 | | | YANG Feng-chang | 山东省肿瘤医院放疗科, CT室 | | | LI Hong-sheng | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | SUN Hong-fu | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | CHEN Jin-hu | 山东省肿瘤医院放疗科, 物理室 | | | LIU Bo | 山东省肿瘤医院放疗科, 物理室 | |
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| Abstract:: |
| Objective To analyze the clinical and dosimetric risk factors for computed tomography(CT) grade of radiation-induced lung injury in lung cancer treated with three-dimensional conformal radiotherapy (3DCRT). Methods Eighty-nine lung cancer patients treated with 3DCRT were enrolled and CT scan images in more than 6 months were retrospectively analyzed. Clinical and dosimetric parameters were reviewed. Radiation-induced lung injuries were classified into 5 grades on CT images. Grade 3 or worse were considered clinically significant. Statistical software SPSS 15.0 was used to analyze the clinical and dosimetric risk factors that influenced the CT grade of radiation-induced lung injury. Results Eight of 89 patients (9.0%) developed grade 0 of radiation-induced lung injury, 13 developed grade 1(14.6%), 24 developed grade 2(27.0%), 23 developed grade 3(25.8%)and 21 developed grade 4(23.6%). Univariable analysis showed that concurrent chemotherapy(CCT), GTV margin, involved ipsilateral lung mean lung dose(IMLD), the percent of involved ipsilateral lung receiving over 15,20,25,30,35,40 and 45 Gy (V 15, V 20, V 25, V 30, V 35, V 40, V 45) were significantly associated with over grade 3 of radiation-induced lung injury . On multivariate logistic regression analysis, CCT, GTV margin and V 20 of ipsilateral lung emerged as statistically significant risk factors of over grade 3 radiation-induced lung injuries CT images. Conclusions CCT, GTV margin and V20 of ipsilateral lung might be clinical and dosimetric risk factors associated with the severe CT grade of radiation-induced lung injury for lung cancer treated with 3DCRT. |
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