| ZHU Shu-chai,CUI Yan-li,LI Juan,LIU Zhi-kun,SHEN Wen-bin,SU Jing-wei,WANG Yu-xiang.Dosimetry analysis on radiation-induced acute esophagitis after three-dimensional conformal radiotherapy for non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2010,30(1):50-53 |
| Dosimetry analysis on radiation-induced acute esophagitis after three-dimensional conformal radiotherapy for non-small cell lung cancer |
| Received:June 02, 2009 |
| DOI： |
| KeyWords:Non-small cell lung cancer Three dimensional conformal radiotherapy Radiation-induced esophagitis DVH |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHU Shu-chai | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China | sczhu@heinfo.net | | CUI Yan-li | 邢台市人民医院放疗科 | | | LI Juan | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | | LIU Zhi-kun | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | | SHEN Wen-bin | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | | SU Jing-wei | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | | WANG Yu-xiang | Department of Radiation Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective To analyze the related factors with radiation-induced esophagitis after three-dimensional conformal radiotherapy for non-small cell lung cancer (NSCLC), in order to explore the predictors for optimizing the treatment planning of NSCLC. Methods From Aug 2000 to Dec 2004, 104 NSCLC patients received radiotherapy and were eligible for this study, 45 cases squamous cell carcinoma, 20 cases adenocarcinoma, 33 cases carrying with cancer cells by test and 6 case with no definitive pathologic feature. 46 patients were treated with three dimensional conformal radiotherapy(3DCRT), the other 58 patients conventional radiotherapy (CRT) before later-course 3DCRT. All the patients received the prescribed dose between 60-78 Gy and the median dose 66 Gy. The correlation of the variables were evaluated by Spearman relationship analysis. The morbidity of radiation-induced esophagitis was analyzed by χ2 test. The multivariate effect on radiation-induced esophagitis was statistically processed by Logistic regression model. Results In 104 patients, the morbidity of radiation-induced esophagitis was 46.2%, including 32 cases at grade 1, 15 cases at grade 2, 1 case at grade 3. Univariate analysis showed the maximal and mean dose of esophagus, the volume of esophagus irradiated, the values of V 40, V 45, V 50, V 55, V 60,LETT45,LETT50,LETT55,LETT60 for the esophagus were correlated with radiation-induced esophagitis. Logistic regression model showed that the maximum dose received by the esophagus was the independent factor of ≥2 grade radiation-induced esophagitis. Conclusions The maxmal dose of esophagus received might be the important factor of radiation-induced esophagitis. |
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