| BAO Yong-xing,LOU Fan,ZHAO Hua-rong,ZHU Hu-hu,MA Yan,WEN Hao.Study on bone marrow mesenchymal stem cells in repairing of radiation induced acute liver injury of rats[J].Chinese Journal of Radiological Medicine and Protection,2010,30(1):22-25 |
| Study on bone marrow mesenchymal stem cells in repairing of radiation induced acute liver injury of rats |
| Received:May 13, 2009 |
| DOI： |
| KeyWords:Bone marrow mesenchymal stem cells Rats Radiation induced liver injury |
| FundProject: |
| Author Name | Affiliation | E-mail | | BAO Yong-xing | Cancer Center of First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China | | | LOU Fan | Cancer Center of First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China | | | ZHAO Hua-rong | Cancer Center of First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China | | | ZHU Hu-hu | Cancer Center of First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China | | | MA Yan | Cancer Center of First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China | | | WEN Hao | Cancer Center of First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China | dr.wenhao@163.com |
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| Abstract:: |
| Objective To investigate the role of mesenchymal stem cells in the repair of radiation induced liver injury. Methods 12 female SD rats were irradiated with 20 Gy 6 MV X-rays on the right lobe of the liver, to establish the model of radiation induced liver injury. The rats were divided randomly into two groups as invention group and control group, and transplanted with 1 ml male mesenchymal suspension or 1 ml normal saline in 4 hours after radiotherapy. The morphological changes of liver were observed. The existence of sex determining gene Y(SRY)and the level of alpha-smooth muscle actin (ɑ-SMA) were detected. Results Some injury of right lobe liver in two groups were observed, and the injury degree of right lobe liver in intervention group were lower than that of control group. The amount of SRY positive cells in the right lobe liver of intervention group was higher than that in the left lobe liver(t=3.77, P＜0.05). The positive expression rate of ɑ-SMA in right lobe liver of intervention group was lower than that of control group. Conclusions Acute radiation induced liver injury could lead BMSCs'homing in order to decrease the degree of liver fibrosis. |
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