| WANG Hao,SHI Pei-ji,ZHOU Xiao-liang,et al.Radiosensitization of nitroindazole derivatives on HeLa cells[J].Chinese Journal of Radiological Medicine and Protection,2010,30(1):20-21 |
| Radiosensitization of nitroindazole derivatives on HeLa cells |
| Received:February 28, 2009 |
| DOI： |
| KeyWords:5-Nitroindazole-3-formyliminodiacetic acid HeLa cells Hypoxia Radiosensiti-zation |
| FundProject:天津市自然科学基金(08JCYBJC07400) |
| Author Name | Affiliation | E-mail | | WANG Hao | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | whcams@gmail.com | | SHI Pei-ji | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | | ZHOU Xiao-liang | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | | WANG Yan | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | | TANG Wei-sheng | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | |
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| Abstract:: |
| Objective To investigate the cytotoxicity and radiosensitization of 5-nitroindazole-3-formyliminodiacetic acid on HeLa cells. Methods HeLa cells in exponential growth phase were incubated in culture media with different doses and the survival rate was determined by MTT assay. The survival rate of cells receiving radiation combined with different doses of medicine was compared with that of the control. Results The cytotoxicity of 5-nitroindazole-3-formyliminodiacetic acid on HeLa cells was very low. The drug had hypoxia radiosensitizing effect on HeLa cells. At doses of 0, 6, 12, 24, 48 and 96 μg/ml under hypoxia ,the survival rate were 0.91, 0.87, 0.84, 0.81, 0.76 and 0.60, respectively.At the dosage of 48 and 96 μg/ml,the survival rate were 0.85 and 0.73 under oxygenous). Conclusions 5-Nitroindazole-3-formyliminodiacetic acid has low cytotoxicity and rediosensitizing effect on HeLa cells. |
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