| NI Jin,DAN Zhi-gang,GAO Fu,SUN Ding,CAI Jian-ming.Studies of modifying effects of fullerene on 60Co-γ irradiated zebrafish[J].Chinese Journal of Radiological Medicine and Protection,2010,30(1):5-8 |
| Studies of modifying effects of fullerene on 60Co-γ irradiated zebrafish |
| Received:December 28, 2008 |
| DOI： |
| KeyWords:Fullerene γ-irradiation Zebrafish Radiomodification |
| FundProject:国家自然科学基金(30200069);解放军总后军队医药卫生课题资助项目(06MA169) |
| Author Name | Affiliation | | NI Jin | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | DAN Zhi-gang | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | GAO Fu | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | SUN Ding | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | CAI Jian-ming | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China |
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| Abstract:: |
| Objective To evaluate the modification of C60 on the radiation effects of 60Co-γ irradiation on zebrafish. Methods The adult and embryonic zebrafish were used as model organisms to examine the potential of C60 to elicit oxidative stress responses on the surviving rate, hatching rate and malformation occurrence, both upon exposure to light or in the dark. Reactive oxygen species (ROS) production and DNA damage were examined as the possible underlying mechanism. Results 500×10－9 nano-C60 waterborne exposure could enhance the γ-irradiation effects by decreasing adult fish survival upon light exposure, which resulted in ROS and DNA damage increasing. The hatching rates were also inhibited with higher malformation, though dark exposure did not make any enhancement, except that the 5000×10－9 C60would inhibit larvae hatching and induced more malformation. Conclusions Waterborne nano-C60 exposure may enhance the radiation effects on zebrafish, ROS production and DNA damage increasing may be the underlying mechanism. |
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