| TAI Guo-mei,ZHANG Jun-ning,WANG Jian-ping,WANG Yi-zong.Relationship between polymorphisms of XRCC1 and the short-term effect of radiotherapy of nasopharygeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2009,29(6):608-610 |
| Relationship between polymorphisms of XRCC1 and the short-term effect of radiotherapy of nasopharygeal carcinoma |
| Received:December 20, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.06.015 |
| KeyWords:XRCC1 Polymorphisms Nasopharygeal carcinoma Radiotherapy |
| FundProject: |
| Author Name | Affiliation | E-mail | | TAI Guo-mei | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | junningzhang@sina.com | | ZHANG Jun-ning | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | WANG Jian-ping | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | WANG Yi-zong | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | |
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| Abstract:: |
| Objective To find the intrinsic influencing factor of radiosensitivity, and to detect the polymorphisms of XRCC1 of the patients suffering from nasopharygeal carcinoma(NPC) and the different short-term curative effect of radiotherapy. Methods XRCC1 Codon Arg399Gln was determined by polymerase chain reaction and ligase detection reaction(PCR-LDR), and the effect of radiotherapy of NPC on mid-therapy and 3 months after finishing radiation were observed. Results On mid-radiotherapy, the retraction rate of Gln/Gln genotype was 0.855±0.026, which was higher than that of Arg/Gln (0.386±0.183) and Arg/Arg genotypes (0.377±0.169) ( F = 11.16, P = 0.0003). The CR rate of 3 months after radiotherapy of the case with Gln/Gln was 100%, Arg/Gln was 76.2%, Arg/Arg was 66.7% ( P >0.05). Conclusion Polymorphisms of XRCC1Arg399Gln could be a predictor for the radiotherapy effect of NPC on mid-radiotherapy. |
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