| XU Xiao-jie,WANG Ling-xue,LIN Jing,DING Li-hua,WANG Rong-fu,QIN Xi,CHENG Long,KANG Lei,YE Qi-nong.Expression of irradiation inducible gene Gadd 45 in population[J].Chinese Journal of Radiological Medicine and Protection,2009,29(6):580-582 |
| Expression of irradiation inducible gene Gadd 45 in population |
| Received:June 11, 2009 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.06.006 |
| KeyWords:Gadd 45 Biological dosimeter Gene expression |
| FundProject:全军医药卫生科研基金(06J021);国家重大科学研究计划(2007CB914603) |
| Author Name | Affiliation | E-mail | | XU Xiao-jie | Beijing Institute of Biotechnology, Beijing 100850, China | yeqn66@yahoo.com | | WANG Ling-xue | Beijing Institute of Biotechnology, Beijing 100850, China | | | LIN Jing | 解放军总医院第一附属医院 | | | DING Li-hua | Beijing Institute of Biotechnology, Beijing 100850, China | | | WANG Rong-fu | 北京大学第一医院 | | | QIN Xi | Beijing Institute of Biotechnology, Beijing 100850, China | | | CHENG Long | Beijing Institute of Biotechnology, Beijing 100850, China | | | KANG Lei | 北京大学第一医院 | | | YE Qi-nong | Beijing Institute of Biotechnology, Beijing 100850, China | |
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| Abstract:: |
| Objective To investigate the difference of Gadd 45 expression in healthy population, and to evaluate the possibility of developing Gadd 45 expression into a new radiation bio-dosimeter. Methods Twenty blood samples from healthy population were collected and the total RNA was extracted from white blood cells and reverse transcribed into cDNA. The method of real-time PCR was used to detect the different level of Gadd 45 expression in human population, with β-actin as an internal control. Results There was a significant difference in Gadd 45 expression among 20 subjects. In addition, the difference was irrelevant to the sex. Conclusion The expression of irradiation-inducible gene Gadd 45 might not be a good bio-dosimeter. |
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