| GUO Long-jia,CHEN Zhi-jian,CHEN Chuang-zhen,HONG Chao-qun,WU Xiao.Expressions of HIF-1α and COX-2 in esophageal squamous cell carcinoma and their correlation with intratumoral MVD[J].Chinese Journal of Radiological Medicine and Protection,2009,29(5):502-505 |
| Expressions of HIF-1α and COX-2 in esophageal squamous cell carcinoma and their correlation with intratumoral MVD |
| Received:November 04, 2008 |
| DOI： |
| KeyWords:Esophageal carcinoma HIF-1α COX-2 Microvascular density Radiotherapy Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | GUO Long-jia | Department of Radiotherapy, Cancer Hospital, Medical College of Shantou University, Shantou 510031, China | | | CHEN Zhi-jian | Department of Radiotherapy, Cancer Hospital, Medical College of Shantou University, Shantou 510031, China | zjchenmd@stu.edu.cn | | CHEN Chuang-zhen | Department of Radiotherapy, Cancer Hospital, Medical College of Shantou University, Shantou 510031, China | | | HONG Chao-qun | 515031 汕头, 广东省汕头大学医学院附属肿瘤医院病理科 | | | WU Xiao | 515031 汕头, 广东省汕头大学医学院附属肿瘤医院病理科 | |
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| Abstract:: |
| Objective To investigate the expressions of HIF-1α,COX-2 and introtumoral microvascular density(MVD) in esophageal squamous cell carcinoma (ESCC),and their impacts on the efficacy of radiotherapy. Methods Expressions of HIF-1α and COX-2 were assessed by immunohistochemistry methods in fifty-five cases of ESCC.Microvessels were labelled in sections of same tissues by CD34 immunohistochemistry.The correlations with clinicopathological features and postradiotherapy survival rates were evaluated and analyzed.Results The MVD ranged from 2 to 29(mean of 11.2±4.1). The positive rates of HIF-1α and COX-2 protein expression were 92.7% and 69.1%, respectively, both of which were not correlated with intratumoral MVD. The expressions of HIF-1α and COX_2 were not correlated with histological grade or the location of the primary tumor. Univariate analysis revealed that 2_year survival rates and median survival time following radiotherapy were not assocaited with the expressions of HIF_1α, COX_2 or MVD. Conclusions MVD and the expressions of HIF-1α and COX-2 in ESCC are not efficient to predict the outcome of ESCC following radiotherapy. |
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