| YANG Rui-jie,JIANG Wei-juan,WANG Jun-jie.Effect of beam energy on quality of IMRT plans for endometrial cancer[J].Chinese Journal of Radiological Medicine and Protection,2009,29(5):495-498 |
| Effect of beam energy on quality of IMRT plans for endometrial cancer |
| Received:October 20, 2008 |
| DOI： |
| KeyWords:Endometrial cancer/radiotherapy Intensity-modulated radiation therapy Beam energy Normal tissue Integral dose |
| FundProject: |
| Author Name | Affiliation | E-mail | | YANG Rui-jie | Department of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100083, China | | | JIANG Wei-juan | Department of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100083, China | | | WANG Jun-jie | Department of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing 100083, China | junjiew920@sohu.com |
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| Abstract:: |
| Objective To investigate the effect of beam energy on the quality of postoperative whole pelvic IMRT plans for endometrial cancer. Methods Computed Tomography (CT) image sets of ten postoperative endometrial cancer patients were acquired and two whole pelvic IMRT plans were created for each patient, one with 6 MV and the other with 18 MV photons. Beam arrangements and optimization constraints were the same for two plans. The dose distribution of the targets, organs at risk and normal tissue was analyzed and compared for plans generated with both energies. Results The mean PTV100 were 95.6% and 95.3% (P=0.26), the Dmean were 52.55 Gy and 52.60 Gy (P=0.54) for the plans with 6- and 18- MV photons, respectively. The mean conformity index were 0.87 and 0.88 (P=0.03). The mean homogeneity index were both 1.10 (P=0.38). The mean integral dose to normal tissue was 2.4% lower with 18 MV plans (P=0.00), the mean V30 and V50 of small intestine and colon were also reduced by 4.2% (P=0.006) and 3.3% (P=0.046),respectively. No statistically significant difference was found for the dose distribution to the other organs at risk between the plans with 6- and 18- MV photons. Conclusions Compared with 6 MV IMRT plans, 18 MV IMRT plans resulted in more conformal dose distribution, better sparing of small intestine and colon, and normal tissue, with comparable PTV coverage and sparing of rectum, bladder, and pelvic bones. |
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